Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Justification for classification or non-classification

Additional information

No information on carcinogenic effects in humans or laboratory animals are available for DEIPA and chronic testing is not a requirement (Annex VII-IX) at this tonnage level (100-1000 tpa). In a limited study, no carcinogenic activity was seen when TIPA was fed to rats at a concentration of 2% in the diet for 2 years (Yamamoto et al. 1989; Yamamoto, 1991). In addition, DEIPA is not expected to be genotoxic in vivo.



Yamamoto K., Eimoto H., Takashima Y., Tsutsumi M., Maruyama H., Denda A., Mori Y., Konishi Y. (1989). Initiation activity of endogenously synthesized N-nitrosobis(2-hydroxypropyl)amine in the rat liver. Cancer Letters 45, 221-225.


Yamamoto K. (1991). Endogenously synthesized N-nitrosobis(2-hydroxypropyl)amine and its carcinogenic potential. J. Nara. Med. Ass. 42, 134-152.