Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 229-764-5
CAS number: 6712-98-7
In a GLP study, conducted according to OECD
guideline 407, groups of 5 female and 5 male Fischer rats were
administered 0 (control), 30, 100 and 1000 mg/kg bw/day of DEIPA (in
water) by oral gavage for 28 days. Recovery was assessed in a two-week
recovery period following a 4-week dosing regime, in additional groups
administered 0 (control) or 1000 mg/kg bw/day. Parameters evaluated
included mortality, detailed clinical observations, functional tests,
ophthalmologic examination, body weight, feed consumption, clinical
chemistry, haematology, urinalysis, selected organ weights, gross and
There were no mortalities or
treatment-related clinical observations at any dose level. The most
significant effects noted were inflammation, hyperplasia and
hyperkeratosis of the non-glandular mucosa of the stomach in rats
receiving 1000 mg/kg bw/day. All treatment-related stomach alterations
were completely resolved following the 2 -week recovery period. Both
sexes administered 1000 mg/kg bw/day showed statistically significant
increases in liver and kidney weights (but no associated tissue
effects), a minimal decrease in haemoglobin concentration and increases
in urea nitrogen, aspartate aminotransferase, total protein, albumin,
triglycerides and calcium. The high dose rats had reduced urine specific
gravity. This was also seen in females at 100 mg/kg bw/day, however this
was not considered significant as there were no associated toxicological
alterations. There was partial or complete recovery of all
treatment-related effects in the high dose group following the 2-week
From the results of this study, an oral
no-observed-adverse-effect level (NOAEL) of 100 mg/kg bw/day has been
determined in the rat for DEIPA.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again