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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2004-01-27 to 2004-05-28
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Key result
Water solubility:
>= 250 g/L
Temp.:
20 °C
pH:
4.6 - 4.7
Remarks on result:
other: Temperature; 19.5-20.5°C
Details on results:
See; Table 1
The flask method test could not be performed because the test substance is miscible with water.
The solubility of the test substance in water was determined as 250 g/L and above as the confirmation value.

   Table 1; The results of the measured solubility in water at

Sample name

Measured solubility

value (g/L)

pH

Sample a

251

4.6

Sample b

250

4.7
Conclusions:
A water solubility of >250 g/l at 20°C and pH 4.6 - 4.7 was determined for the substance in accordance with OECD 105 and in compliance with GLP. The result is considered reliable.

Description of key information

Water solubility [tetrahydrofurfuryl alcohol]: >250 g/l at 20°C and pH 4.6 - 4.7 (OECD 105)

Key value for chemical safety assessment

Water solubility:
250 g/L
at the temperature of:
20 °C

Additional information

A measured water solubility value of >250 g/l (250,000 mg/l) at 20°C and pH 4.6 -4.7 was determined for the substance in accordance with OECD 105 and in compliance with GLP. Although a full study was not performed because the substance was said to be miscible with water, confirmatory testing was performed at 250 g/l using GC analysis. This deviation was not considered to affect the reliability of the result nor the chemical safety assessment. The result is considered to be reliable and selected as key study. In a handbook or collection of reliable data which has been subjected to peer review and in which original sources are traceable, the substance was reported to be miscible with water. Also, the substance was reported as easily soluble in a secondary source to which no reliability could be assigned.