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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2014-06-18 to 2014-06-19
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
isoteniscope
Key result
Test no.:
#1
Temp.:
25 °C
Vapour pressure:
142 Pa
Remarks on result:
other: The result was extrapolated from measurements made at elevated temperature and therefore the reviewer has attempted to assess the uncertainty associated with the extrapolation.
Key result
Test no.:
#2
Temp.:
20 °C
Vapour pressure:
ca. 100 Pa
Key result
Test no.:
#3
Temp.:
30 °C
Vapour pressure:
ca. 180 Pa
Key result
Test no.:
#4
Temp.:
40 °C
Vapour pressure:
ca. 340 Pa
Key result
Test no.:
#5
Temp.:
50 °C
Vapour pressure:
ca. 600 Pa
Transition / decomposition:
no

Recorded temperatures, manometer readings and resulting calculated values of vapour pressure are shown in the tables below

Run 1

Table 1: vapour pressure data

LHS column (cmHg)

RHS column (cmHg)

Temperature (°C)

Vapour pressure (Pa)

Temperature (K)

Reciprocal temperature (1/K)

log10VP

56.1

14.9

157.0

54928.82

430.15

0.002324770

4.739800236

55.6

15.4

156.0

53595.59

429.15

0.002330188

4.729129073

54.5

16.5

154.1

50662.50

427.25

0.002340550

4.704686617

53.9

17.1

152.8

49062.63

425.95

0.002347693

4.690750839

53.2

17.8

151.6

47196.12

424.75

0.002354326

4.673906282

52.5

18.5

150.4

45329.61

423.55

0.002360996

4.656381937

51.4

19.6

148.3

42396.51

421.45

0.002372761

4.627330140

50.7

20.3

147.0

40530.00

420.15

0.002380102

4.607776604

50.0

21.0

145.6

38663.49

418.75

0.002388060

4.587301018

49.3

21.7

144.2

36796.97

417.35

0.002396070

4.565812102

48.7

22.3

142.9

35197.11

416.05

0.002403557

4.546506947

47.6

23.4

140.4

32264.01

413.55

0.002418087

4.508718386

47.1

23.9

139.2

30930.79

412.35

0.002425124

4.490391005

46.9

24.1

138.1

30397.50

411.25

0.002431611

4.482837867

46.0

25.0

136.4

27997.70

409.55

0.002441704

4.447122315

45.7

25.3

135.4

27197.76

408.55

0.002447681

4.434533188

45.3

25.7

134.0

26131.18

407.15

0.002456097

4.417159091

44.8

26.2

132.8

24797.96

405.95

0.002463358

4.394415964

44.4

26.6

131.6

23731.38

404.75

0.002470661

4.375323022

43.9

27.1

130.0

22398.16

403.15

0.002480466

4.350212302

43.5

27.5

128.6

21331.58

401.75

0.002489110

4.329023003

43.2

27.8

127.5

20531.64

400.65

0.002495944

4.312423741

 

A plot of log10[vapour pressure (Pa)] versus reciprocal temperature [1/T(K)] for Run 1 gives the following statistical data using an unweighted least square treatment

Slope = -2.53x103

Standard error in slope = 11.7

Intercept = 10.6

Standard error in intercept = 2.81x10-2

The results indicated the following vapour pressure relationship:

log10[vapour pressure (Pa)] = -2.53x103/temp (K) + 10.6

This yields a vapour pressure (Pa) at 298.15 K with a common logarithm of 2.14

 

 

Run 2

Table 2: vapour pressure data

LHS column (cmHg)

RHS column (cmHg)

Temperature (°C)

Vapour pressure (Pa)

Temperature (K)

Reciprocal temperature (1/K)

log10VP

54.9

16.1

154.7

51729.08

427.85

0.002337268

4.713734746

54.5

16.5

153.8

50662.50

426.95

0.002342195

4.704686617

54.0

17.0

152.9

49329.28

426.05

0.002347142

4.693104744

53.2

17.8

151.5

47196.12

424.65

0.002354880

4.673906282

52.6

18.4

150.4

45596.25

423.55

0.002360996

4.658929126

52.0

19.0

149.2

43996.38

422.35

0.002367705

4.643416960

51.4

19.6

148.2

42396.51

421.35

0.002373324

4.627330140

50.8

20.2

146.9

40796.64

420.05

0.002380669

4.610624447

50.1

20.9

145.5

38930.13

418.65

0.002388630

4.590285872

49.5

21.5

144.3

37330.26

417.45

0.002395496

4.572061051

48.9

22.1

142.8

35730.39

415.95

0.002404135

4.553037814

48.3

22.7

141.5

34130.53

414.65

0.002411672

4.533142985

47.5

23.5

139.6

31997.37

412.75

0.002422774

4.505114262

47.0

24.0

138.6

30664.14

411.75

0.002428658

4.486630856

46.8

24.2

137.7

30130.86

410.85

0.002433978

4.479011459

46.2

24.8

136.6

28530.99

409.75

0.002440513

4.455316793

45.3

25.7

134.1

26131.18

407.25

0.002455494

4.417159091

45.0

26.0

132.9

25331.25

406.05

0.002462751

4.403656621

44.5

26.5

131.6

23998.03

404.75

0.002470661

4.380175525

44.0

27.0

130.0

22664.80

403.15

0.002480466

4.355351942

43.6

27.4

128.8

21598.22

401.95

0.002487872

4.334418035

43.3

27.7

127.6

20798.29

400.75

0.002495321

4.318027618

43.0

28.0

126.3

19998.36

399.45

0.002503442

4.300994279

 

A plot of log10[vapour pressure (Pa)] versus reciprocal temperature [1/T(K)] for Run 2 gives the following statistical data using an unweighted least square treatment

Slope = -2.53x103

Standard error in slope = 9.85

Intercept = 10.6

Standard error in intercept = 2.38x10-2

The results indicated the following vapour pressure relationship:

log10[vapour pressure (Pa)] = -2.53x103/temp (K) + 10.6

This yields a vapour pressure (Pa) at 298.15 K with a common logarithm of 2.15

 

Run 3

Table 3: vapour pressure data

LHS column (cmHg)

RHS column (cmHg)

Temperature (°C)

Vapour pressure (Pa)

Temperature (K)

Reciprocal temperature (1/K)

log10VP

56.9

14.1

159.2

57061.97

432.35

0.002312941

4.756346789

55.8

15.2

157.7

54128.88

430.85

0.002320993

4.733429054

55.1

15.9

156.5

52262.37

429.65

0.002327476

4.718189087

54.1

16.9

154.6

49595.92

427.75

0.002337814

4.695445960

53.3

17.7

153.5

47462.76

426.65

0.002343842

4.676353018

52.5

18.5

152.0

45329.61

425.15

0.002352111

4.656381937

51.0

20.0

149.0

41329.93

422.15

0.002368826

4.616264714

50.0

21.0

147.1

38663.49

420.25

0.002379536

4.587301018

49.0

22.0

144.6

35997.04

417.75

0.002393776

4.556266784

48.7

22.3

144.1

35197.11

417.25

0.002396645

4.546506947

47.7

23.3

142.0

32530.66

415.15

0.002408768

4.512292846

47.0

24.0

139.6

30664.14

412.75

0.002422774

4.486630856

46.0

25.0

137.4

27997.70

410.55

0.002435757

4.447122315

45.5

25.5

136.0

26664.47

409.15

0.002444091

4.425933016

44.9

26.1

134.0

25064.61

407.15

0.002456097

4.399060869

44.0

27.0

130.8

22664.80

403.95

0.002475554

4.355351942

43.2

27.8

128.0

20531.64

401.15

0.002492833

4.312423741

42.4

28.6

125.7

18398.49

398.85

0.002507208

4.264782107

 

A plot of log10[vapour pressure (Pa)] versus reciprocal temperature [1/T(K)] for Run 3 gives the following statistical data using an unweighted least square treatment

Slope = -2.49x103

Standard error in slope = 13.3

Intercept = 10.5

Standard error in intercept = 3.18x10-2

The results indicated the following vapour pressure relationship:

log10[vapour pressure (Pa)] = -2.49x103/temp (K) + 10.5

This yields a vapour pressure (Pa) at 298.15 K with a common logarithm of 2.17

 

Summary of results

The extrapolated vapour pressure for each measurement is summarised in Table 4

Table 4: summary of vapour pressure data

run

log10[vapour pressure (Pa)] at 25°C

1

2.14

2

2.15

3

2.17

Mean

2.15

vapour pressure

142

 

The test item did not change in appearance under the conditions of the study

Reviewer's comment: The result (142 Pa) was extrapolated from measurements made at elevated temperature and therefore the reviewer has attempted to assess the uncertainty associated with the extrapolation. Based on the raw data, the reviewer has estimated the vapour pressure of the substance to be 142±13 Pa at 25°C.

Using the regression in the study report, the following vapour pressures at different temperatures were obtained by the reviewer.

 

Run 1 (log VP)

Run 2 (log VP)

Run 3 (log VP)

Average

Vapour pressure (Pa)

20

1.969606

1.969606

2.006055

1.981756

95.8861

30

2.254297

2.254297

2.286244

2.264946

184.0542

40

2.520805

2.520805

2.548539

2.530049

338.8828

50

2.770819

2.770819

2.7946

2.778746

600.8218

Conclusions:
A vapour pressure of 142±13 Pa at 25°C was determined for the substance in accordance with OECD 104 and in compliance with GLP. The result is considered reliable.

Description of key information

Vapour pressure [tetrahydrofurfuryl alcohol]: 142±13 Pa at 25°C (OECD 104)

Key value for chemical safety assessment

Vapour pressure:
142 Pa
at the temperature of:
25 °C

Additional information

The vapour pressure of the submission substance has been recently determined. A vapour pressure of 142±13 Pa at 25°C was obtained for the substance using the isoteniscope method in accordance with OECD 104 and in compliance with GLP. The result was extrapolated from measurements at elevated temperature, the reviewer has therefore attempted to assess the uncertainty associated with the extrapolation. In addition, using the regression equations in the study report, vapour pressure values of approximately 100 Pa at 20°C, 180 Pa at 30°C, 340 Pa at 40°C and 600 Pa at 50°C were obtained by the study reviewer. The result is considered to be reliable and selected as key study. The key study is supported by a measured vapour pressure of 186 Pa at 25°C which was obtained for the substance in accordance with OECD 104 and in compliance with GLP. Also, a vapour pressure of 107 Pa at 25°C was reported from a reliable peer-reviewed source (Daubert and Danner 1989). The key study was selected as the most recent of the available reliable studies.

In secondary sources to which reliability could not be assigned, vapour pressures of 31 Pa at 20°C and 670 Pa at 50°C were reported for the substance. Similarly, in another secondary source (Pennakem 1973), raw vapour pressure results between temperature of 41 - 178°C were reported for the substance. Vapour pressure value of 2.3 mmHg (307 Pa) at 41.6°C was obtained for tetrahydrofurfuryl alcohol. Vapour pressure values of 82 Pa and 116 Pa at 20°C and 25°C were extrapolated by the reviewer from the raw data.

Variations in the vapour pressure of the substance may occur depending on the purity of the test substance and the test method used, however in the absence of a more reliable data, the vapour pressure result reported in the key study is used as a worst case value for assessment purposes.