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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2004-11-25 to 2005-06-26
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
no
GLP compliance:
yes
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Analytical method:
gas chromatography
Key result
Type:
Pow
Partition coefficient:
0.722
Temp.:
24.7 °C
pH:
ca. 6.7 - ca. 6.8
Key result
Type:
log Pow
Partition coefficient:
-0.14
Temp.:
24.7 °C
pH:
ca. 6.7 - ca. 6.8
Details on results:
See Table 2

Table 2 : Measurement results of partition coefficient (Pow)

            Pow=Co/Cw           log Pow            
 MeasuredValue  Mean  TotalMean  Standarddeviation  Measuredvalue  Mean  Totalmean  Standarddeviation  Maximumdifferance
 Measurement   condition-1  a  0.653  0.663    0.722 0.0471        -0.19  -0.18     -0.14    0.0289   0.07 
 b  0.674  -0.17
  Measurement   condition-2  a  0.737  0.743     -0.13  -0.13   
 b  0.749  -0.13
  Measurement   condition-3  a  0.762  0.761     -0.12  -0.12   
 b  0.759  -0.12
Conclusions:
A log Kow of -0.14 at 24.7°C and pH 6.7 - 6.8 was determined for the substance in accordance with OECD 107 and in compliance with GLP. The result is considered reliable.

Description of key information

Partition coefficient [tetrahydrofurfuryl alcohol]: -0.14 at 24.7°C and pH 6.7 - 6.8 (OECD 107)

Key value for chemical safety assessment

Log Kow (Log Pow):
-0.14
at the temperature of:
24.7 °C

Additional information

A measured log Kow of -0.14 at 24.7°C and pH 6.7 - 6.8 was determined for the substance in accordance with OECD 107 and in compliance with GLP. The result is considered to be reliable and selected as key study. In a secondary source to which reliability could not be assigned, a limit log Kow of <3 was reported for the substance.

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