Registration Dossier
Registration Dossier
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EC number: 911-369-0 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002-02-26
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- no
- Type of method:
- flask method
- Key result
- Water solubility:
- 186 mg/L
- Temp.:
- 23 °C
- Remarks on result:
- other: The pH is not considered to be critical based on the absence of acidic and basis structural features in its molecular structure. Therefore the pH of the solution is expected to be around 7.
- Conclusions:
- The water solubility of Cyclacet was determined to be 186 mg/l at 23 °C using a reliable non-GLP study equivalent to OECD TG 105 using the shake flask method.
- Executive summary:
The water solubility of Cyclacet was determined to be 186 mg/l at 23°C using a study equivalent to OECD TG 105 using the shake flask method.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Major OECD 105 requirements were not followed; results are not published following OECD 105 standard. HPLC shows only 88% of purity for the main two components. GLP has not been documented, however, there are indications that this study was part of a study program for which GLP has been demonstrated with other study reports. Reference to OECD 105 and method is not stated but flask method is assumed similar to other studies made under this project in the Bayer laboratory
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- not specified
- Type of method:
- flask method
- Water solubility:
- 188 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- Remarks on result:
- other: No pH value was specified in the study. The pH is not considered to be critical based on the absence of acidic and basis structural features in its molecular structure. Therefore the pH of the solution is expected to be around 7.
- Details on results:
- The temperature range was ± 0.5°C.
- Conclusions:
- The water solubility of Cyclacet was determined to be 188 mg/l at 20°C using a study equivalent OECD TG 105 using the flask method. GLP status unknown.
- Executive summary:
The water solubility of Cyclacet was determined to be 188 mg/l at 20°C using study equivalent OECD TG 105 using the flask method.
Referenceopen allclose all
Description of key information
The water solubility of Cyclacet was determined to be 186 mg/l at 23°C using a study equivalent to OECD TG 105 using the shake flask method.
Key value for chemical safety assessment
- Water solubility:
- 186 mg/L
- at the temperature of:
- 23 °C
Additional information
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