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EC number: 911-369-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20/03/1980 - 30/08/1980
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- tricyclo[5.2.1.0²,⁶]dec-3-en-8-yl acetate; tricyclo[5.2.1.0²,⁶]dec-4-en-8-yl acetate
- EC Number:
- 911-369-0
- Molecular formula:
- C12H16O2
- IUPAC Name:
- tricyclo[5.2.1.0²,⁶]dec-3-en-8-yl acetate; tricyclo[5.2.1.0²,⁶]dec-4-en-8-yl acetate
- Test material form:
- liquid
1
Test animals
- Species:
- rat
- Strain:
- other: TacN(SD)fBR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Taconic Farms (Germantown, N.Y.)
- Weight at study initiation: 180-280 grams
- Fasting period before study: animals were fasted overnight
- Housing: the animals were housed singly in wire cages
- Diet: Purina Rodent Laboratory Chow 5001 ad libitum
- Water: ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
Animals were kept under standard laboratory conditions meeting the standards described in the "Guide for the care and use of laboratory animals" (DHEW Publication No. (NIH) 78-23 Revised 1978).
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- ethanol
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): 0.5 ml/100 g body weight - Doses:
- Preliminary assay: 4.0, 4.5 and 5.0 g/kg bw.
Definitive study: 3.5, 4.0, 4.5, 5.0 and 5.6 g/kg bw. - No. of animals per sex per dose:
- Preliminary study: 1 male and 1 female per dose
Definitive study: 8 males and 8 females per dose - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed for mortality and pharmacotoxic signs at 1, 3, 5 and 24 hours following dosing and twice daily (once daily on weekends) for the remainder of the 14 day observation period. Surviving animals were weighed at the end of the observation period.
- Necropsy of survivors performed: yes - Statistics:
- LD50 determined by Probit analysis
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 750 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 2 020 - <= 3 740
- Remarks on result:
- other: This value is the key value
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 350 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 2 600 - <= 4 320
- Mortality:
- Most deaths occurred within 24 hours after dosing.
- Clinical signs:
- other: At 3.5 g/kg ataxia or adoption of the prone position were observed in all of males. All the females adopted the prone position.; the signs were observed in the first twenty-four hours and survivors had recovered by 48 hours after having been dosed. Simila
- Gross pathology:
- There were no signs indicative of toxicity in any of the animals necropsied at term. In animals that died the only signs were of yellow fluid in the stomach and intestines and reddish fluid in the intestines.
Any other information on results incl. tables
Summary of mortality
Dose level |
Mortality |
||
Male |
Female |
Total |
|
3.5 g/kg bw |
6/8 |
7/8 |
13/16 |
4.0 g/kg bw |
5/8 |
8/8 |
13/16 |
4.5 g/kg bw |
4/8 |
5/8 |
9/16 |
5.0 g/kg bw |
6/8 |
8/8 |
14/16 |
5.6 g/kg bw |
7/8 |
6/8 |
13/16 |
Applicant's summary and conclusion
- Interpretation of results:
- other: not acute harmful
- Remarks:
- according to EU CLP (EC 1272/2008 and its amendments)
- Conclusions:
- The LC50 is 2750 mg/kg bw based on a similar to OECD TG 401 study. The LC50 is based on the lower LC50 for females.
GHS: For GHS this substance need to be classified as Acute Tox 5 (H303) - Executive summary:
The acute oral toxicity of the test substance towards rats was investigated according to methodology comparable to OECD Guideline 401 and under GLP conditions. Based on the results of a preliminary assay, the test substance was dosed at 3.5, 4.0, 4.5, 5.0 and 5.6 g/kg bw in the main test. Mortality was observed in all doses. The LD50 values were determined to be 3.35 (2.60 - 4.32) and 2.75 (2.02 - 3.74) g/kg for male and female rats respectively, under the conditions of this test. The value of 2750 will be used as the key value.
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