Registration Dossier

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Cyclacet's EC10/NOEC of Daphnia is 1.8 mg/l based on read across from Cyclaprop and using conversion to Cyclacet.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
1.8 mg/L

Additional information

The long-term Daphnia toxicity for Cyclacet is derived from Cyclaprop using its acute / chronic ratio, which is used for read across to Cyclacet. Below the executive summary of Cyclaprop is presented. The read across justification and the conversion can be found in the Aquatic Endpoint summary.

Cyclaprop and its long-term Daphnia toxicity

The chronic toxicity of Cyclaprop towards Daphnia magna was investigated according to OECD guideline 211 under GLP. Daphnids were exposed to nominal concentrations of 0.11, 0.33, 1.0, 3.0 and 9.0 mg/l for 21 days in a flow-through system. Mean measured concentrations were within 20% of the nominal concentrations, therefore nominal concentrations were used to calculate the results. The NOEC and EC50 for survival were 1 and 1.8 mg/l, respectively. The NOEC and EC50 for reproduction were 1 and 2.6 mg/l, respectively. Some issues with oily slick in the test chambers were seen presenting potentially physical effects. At the test concentrations, however, no differentiation could be made between physical and systemic effects and therefore the above mentioned values are used for risk assessment.