Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
911-369-0
CAS no.:
-
Index number:
Molecular formula:
SMILES:
InChI:
Type of substance:
Multi constituent substance
Origin:
Organic
Registered compositions:
11
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:

Hazard classification & labelling

Warning! According to the classification provided by companies to ECHA in REACH registrations this substance is very toxic to aquatic life with long lasting effects and causes serious eye irritation.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is harmful to aquatic life with long lasting effects.

Breakdown of all 16 C&L notifications submitted to ECHA

Aquatic Chronic 1 H410
Eye Irrit. 2 H319
Aquatic Chronic 3 H412
Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 12 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: air care products, perfumes and fragrances, polishes and waxes, washing & cleaning products, cosmetics and personal care products and biocides (e.g. disinfectants, pest control products).

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).

This substance can be found in complex articles, with no release intended: machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines). This substance can be found in products with material based on: fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys). This substance is intended to be released from scented: clothes, paper products and CDs.

This substance is used in the following products: polishes and waxes, washing & cleaning products and cosmetics and personal care products.

This substance is used in the following areas: agriculture, forestry and fishing and health services. This substance is used for the manufacture of: .

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, roller or brushing applications, non-industrial spraying, treatment of articles by dipping and pouring and closed processes with no likelihood of exposure.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid and outdoor use.

This substance is used in the following products: perfumes and fragrances, washing & cleaning products, cosmetics and personal care products, air care products, biocides (e.g. disinfectants, pest control products) and polishes and waxes.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, mixing in open batch processes, laboratory work, closed, continuous processes with occasional controlled exposure and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: washing & cleaning products, metal surface treatment products, perfumes and fragrances, pharmaceuticals, photo-chemicals and cosmetics and personal care products.

This substance is used in the following areas: health services. This substance is used for the manufacture of: chemicals, and machinery and vehicles.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, closed batch processing in synthesis or formulation and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates) and of substances in closed systems with minimal release.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; avoid release to the environment; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If eye irritation persists get medical advice/attention. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • AROGREEN, S.L., Compositor Verdi, 84 08191 Rubí Barcelona Spain
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED(Guangdong CPD-CHEM New Material Technology Co., Ltd), Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED(Jiangsu Xinrui Aromatics Ltd), Regus Harcourt Centre D02 HW77 Dublin Ireland
  • EcoGreen Fine Chemicals B.V., Lichtenauerlaan 102-120 3062ME Rotterdam Netherlands
  • Givaudan France SAS - OR1, 55, Rue de la voie des Bans CS500024 95102 Argenteuil Cedex France
  • Givaudan France SAS - OR6, 55, Rue de la voie des Bans 95102 Argenteuil Cedex France
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden
  • IFF NL 1, Liebergerweg 72-98 1221 JT Hilversum Netherlands
  • International Flavors & Fragrances I.F.F. (Nederland) B.V., Liebergerweg 72-98 1221 JT Hilversum Netherlands
  • Intertek Deutschland GmbH IBVC, Stangenstr. 1 70771 Leinfelden-Echterdingen Germany
  • Intertek Deutschland GmbH IBVO, Stangenstr.1 70771 Leinfelden- Echterdingen Germany
  • Symrise Granada, S.A.U., Crta. Armilla Km 2,5 18100 Armilla Granada Spain
  • IFF OR NL2, International Flavors & Fragrances I.F.F. (Nederland) B.V. Liebergerweg 72-98 1221JT Hilversum Noord-Holland Netherlands

Substance names and other identifiers

Reaction mass of 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate and tricyclo[5.2.1.02,6]dec-4-en-8-yl acetate
REACH pre-registration
3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-6-yl acetate
Registration dossier
3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl acetate
C&L Inventory
Cyclacet
Registration dossier
Cyclacet
Registration dossier
Cyclacet 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl acetateAcetoxydihydrodicyclopentadiene (Mixture of Isomers) Tricyclo[5.2.1.0(2,6)]dec-3-enyl acetateVerdyl Acetate Jasmacyclene HerbafloratTricyclodecenyl acetate
Registration dossier
Jasmacyclene
Registration dossier
N/A
Registration dossier
Reaction mass of 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-5-yl acetate and 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl
Registration dossier
Reaction mass of 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-5-yl acetate and 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate
C&L Inventory, Registration dossier
Reaction mass of 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-5-yl acetate and 3a,4,5,6,7,7ahexahydro-4,7-methanoinden-6-yl
Registration dossier
Reaction mass of 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate and tricyclo[5.2.1.02,6]dec-4-en-8-yl acetate
C&L Inventory
Verdyl acetate
Registration dossier
Cyclacet
Registration dossier
Herbaflorat
Registration dossier
Jasmacyclene
Registration dossier
Verdyl Acetate
Registration dossier

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 8 studies submitted
  • 3 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [3]
C Form
Liquid (67%), Other (33%) [3]
C Odour
Other (100%) [3]
C Substance type
Organic (100%) [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)
Form
Liquid (100%)
Colour
colourless (100%)

Melting/freezing point

Study results
  • 4 studies submitted
  • 3 studies processed
R Melting / freezing point
-20 - -10.3 °C @ 101.32 kPa [3]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Melting / freezing point at 101 325 Pa
-20 - -10.3 °C

Boiling point

Study results
  • 5 studies submitted
  • 3 studies processed
R Boiling point
216 - 246.8 °C @ 97.28 - 101.325 kPa [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Boiling point at 101 325 Pa
216 - 246.8 °C

Density

Study results
  • 6 studies submitted
  • 3 studies processed
R Density
1.07 g/cm³ @ 20 °C [1]
R Relative density
1.073 @ 20 °C [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Relative density at 20°C
1.073

Vapour pressure

Study results
  • 4 studies submitted
  • 3 studies processed
R Vapour pressure
2.12 - 10.1 Pa @ 23 - 25 °C [3]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Vapour pressure
2.12 - 10.105 Pa @ 23 - 25 °C

Partition coefficient

Study results
  • 5 studies submitted
  • 3 studies processed
R Log Pow
3.9 - 4.2 @ 25 - 30 °C and pH 5.92 - 7.1 [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Log Kow (Log Pow)
3.9 - 4.2 @ 30 °C

Water solubility

Study results
  • 5 studies submitted
  • 3 studies processed
R Water solubility (mass/vol.)
186 - 576.4 mg/L @ 20 - 23 °C and pH 6.1 [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Water solubility
186 - 576.4 mg/L @ 20 - 23 °C

Solubility in organic solvents / fat solubility

Study results
  • 2 studies submitted
  • 1 study processed
R Acetonitrile
1 000 g/L [1]
R Dimethylformamide
1 000 g/L [1]
R Methanol
1 000 g/L [1]
R Toluene
1 000 g/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Solubility in organic solvents at 20 °C
1 000 g/L

Surface tension

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Surface tension at 20 °C
38.826 mN/m

Flash point

Study results
  • 3 studies submitted
  • 3 studies processed
R Flash point
110 - 111 °C @ 97.58 - 101.32 kPa [3]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Flash point at 101 325 Pa
110 - 111 °C

Auto flammability

Study results
  • 3 studies submitted
  • 2 studies processed
R Autoflammability / self-ignition
400 °C @ 99.73 - 101.05 kPa [2]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Autoflammability / self-ignition at 101 325 Pa
400 °C

Flammability

Study results
  • 7 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified 3
Exposure cons.
Other 1
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Flammability
Non flammable (67%), Not classified (33%)

Explosiveness

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Oxidising
Oxidising (33%), Non oxidising (33%), No (33%)

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 3 studies submitted
  • 1 study processed
C Dissociating properties
No (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
R Summaries
  • 3 summaries submitted
  • 1 summary processed
pKa at 20 °C
0

Viscosity

Study results
  • 4 studies submitted
  • 3 studies processed
R dynamic viscosity (in mPa s)
10.17 - 31.45 [4]
R kinematic viscosity (in mm²/s)
19.8 - 29.393 [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Dynamic viscosity at 20 °C
10.17 - 31.45 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Hydrolysis

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 1 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Half-life for hydrolysis
1 years @ 25 °C

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 8 studies submitted
  • 4 studies processed
C Interpretation of results
Readily biodegradable (75%), Not readily biodegradable (25%) [4]

Type of Study provided
Studies with data
Key study 3 1 1
Supporting study 1
Weight of evidence 2
Other
Data waiving
no waivers
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Biodegradation in water
Under test conditions no biodegradation observed (67%), Readily biodegradable (33%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Half-life in freshwater
15 - 17 days @ 12 - 25 °C
Half-life in freshwater sediment
4.5 months @ 15 °C

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Half-life in soil
30 - 90 days @ 22 - 25 °C

Bioaccumulation: aquatic / sediment

Study results
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence 2 3
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Bioaccumulation Factor (BCF) - L/kg ww
35.11 - 412 L/kg ww

Bioaccumulation: terrestrial

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation Factor (BCF) - L/kg ww
96.2 L/kg ww

Adsorption/desorption

Study results
  • 6 studies submitted
  • 3 studies processed
R Koc
66.4 - 1 500 dimensionless @ 25 °C [3]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence 1 3
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Koc at 20°C
66.4 - 417

Henrys law constant (H)

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Henry's law constant
2.44 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 3 summaries submitted
  • 3 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 10.4 - 250 µg/L (3)
Intermittent releases (freshwater) 240 µg/L (1)
Marine water 1.04 - 25 µg/L (3)
Intermittent releases (marine water) 24 µg/L (1)
Sewage treatment plant (STP) 5.3 mg/L (2)
Sediment (freshwater) 106 - 11 300 µg/kg sediment dw (3)
Sediment (marine water) 10.6 - 1 130 µg/kg sediment dw (3)
Hazard for Air
Air No hazard identified (3)
Hazard for Terrestrial Organism
Soil 15.2 - 5 600 µg/kg soil dw (3)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 3 studies submitted
  • 3 studies processed
P/RResults
LC50 (4 days) 15.8 - 60 mg/L [3]
LC0 (4 days) 10.9 mg/L [1]
LC100 (4 days) 23.1 mg/L [1]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 4 studies submitted
  • 2 studies processed
P/RResults
NOEC (33 days) 800 - 3 400 µg/L [5]
EC10 (33 days) 910 µg/L [2]

Type of Study provided
Studies with data
Key study 2 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
EC50 (48 h) 25 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 4 studies submitted
  • 2 studies processed
P/RResults
NOEC (21 days) 1 mg/L [4]
EC50 (21 days) 1.8 - 2.6 mg/L [4]

Type of Study provided
Studies with data
Key study 1 1 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 3 studies submitted
  • 3 studies processed
P/RResults
EC50 (72 h) 6.4 - 31.26 mg/L [5]
NOEC (72 h) 1 - 3.2 mg/L [2]
LOEC (72 h) 3.2 - 10 mg/L [2]
EC10 (72 h) 2 - 4.116 mg/L [2]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
EC50 for freshwater algae
6.4 - 31.26 mg/L
EC10 or NOEC for freshwater algae
2 - 3.2 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
EC50 (30 min) 245 mg/L [2]
EC10 (30 min) 53 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
EC50 for microorganisms
245 mg/L
EC10 or NOEC for microorganisms
20 - 53 mg/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC10 / LC10 or NOEC for freshwater sediment
8.15 - 11.3 mg/kg sediment dw

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
NOEC (56 days) 158 mg/kg soil dw [1]
EC10 (56 days) 45.1 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
57 mg/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 6 studies submitted
  • 1 study processed
P/RResults
other: (28 days) 2.12 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 3
Exposure cons.
Other 1
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
2.12 mg/kg soil dw

Toxicity to terrestrial plants

Study results
  • 6 studies submitted
  • 2 studies processed
P/RResults
NOEC (28 days) 2.12 mg/kg soil dw [1]
EC10 (21 days) 10.9 mg/kg soil dw [1]
EC10 (14 days) 17.2 - 92 mg/kg soil dw [6]

Type of Study provided
Studies with data
Key study 1 1 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons.
Other 1
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Long-term EC10 / LC10 / NOEC
2.12 - 56 mg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 6 studies submitted
  • 2 studies processed
P/RResults
NOEC (28 days) 2.12 - 100 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study 1 1 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 987 µg/m³ developmental toxicity / teratogenicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 280 µg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 174 µg/m³ developmental toxicity / teratogenicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 100 µg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 100 µg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Oral: 50 %
Dermal: 50 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 6 studies submitted
  • 3 studies processed
P/RResults
LD50 2 750 - 5 000 mg/kg bw (rat) [5]
M/CInterpretations of results
Not classified [1]

Type of Study provided
oral
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
dermal
  • 5 studies submitted
  • 3 studies processed
P/RResults
LD50 2 000 - 5 000 mg/kg bw (rat) [3]
M/CInterpretations of results
Not classified [1]

dermal
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 5 000 mg/kg bw
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: eye
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irritating)
Respiratory
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2 1 1
Supporting study 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 9 studies submitted
  • 3 studies processed
P/RResults
NOAEL (rat): 1 125 - 1 504.6 mg/kg bw/day [3]

Type of Study provided
Study data: oral
Studies with data
Key study 3
Supporting study 2 1 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Oral route - systemic effects:
No adverse effect observed NOAEL 1 125 mg/kg bw/day (subacute, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 7 1 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: in vivo
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No study available

Carcinogenicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 2
Study data: developmental
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2 1
Supporting study 1
Weight of evidence 3 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 1 125 mg/kg bw/day (subacute, rat)
Effect on developmental toxicity
Oral route:
Adverse effect observed NOAEL 20 mg/kg bw/day (subchronic, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant