Registration Dossier

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
0.015 mg/L
Assessment factor:
1 000
Extrapolation method:
assessment factor
PNEC freshwater (intermittent releases):
0.15 mg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0.002 mg/L
Assessment factor:
10 000
Extrapolation method:
assessment factor
PNEC marine water (intermittent releases):
0.15 mg/L

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
1.32 mg/L
Assessment factor:
100
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
0.048 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
0.005 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
0.035 mg/kg soil dw
Extrapolation method:
equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Primary producers (aquatic plants or algae):

In a 72 h growth inhibition test on freshwater green alga Desmodesmus subspicatus according to relevant guideline and performed complient to GLP (key study, reliability category 1) 2-Chlorobenzaldehyd was found to inhibit the growth after 72 h with the following effect values (geometric mean measured exposure concentrations, growth reduction, mg/L): NOEC = 2.25; LOEC = 7.41; EC10 = 2.84; EC20 = 3.46; EC50 = 16.8.

Primary consumers (aquatic invertebrates):

The reliable (with restrictions, RL 2) experimental key study was performed close to guideline OECD 202. The test duration however is only 24h (according to OECD 202 part I (1984)) instead of 48 h. The validity criteria are fulfilled and a reference substance (potassium dichromate) confirms the reliability of the study. The values for acute toxicity of 2 -Chlorobenzaldehyde on Daphnia magna are

EC0 = 21 mg/L

EC10 = 24 mg/L

EC50 = 30 mg/L.

Secondary consumers (fresh water fish):

The key study from Hoechst on Brachydanio rerio was performed according to OECD guideline 203 with a static system. Determination of actual test concentrations had been precluded because of substance instability (reliability category 2). The 96h LC50 value for Brachydanio rerio determined in this study is 14.83 mg/L.

Toxicity to microorganisms:

In a respiration inhibition test with acitvated sludge from a municipal sewage treatment plant performed according to OECD 209 and GLP (reliability category 1) the test item had been found to inhibit microbial respration by half at a concentration of 132 mg/L (EC50, 95% CI 60.3 - 331 mg/L ).

Thus, for the freshwater compartment of the three trophic levels tested, testing for acute fish toxicity resulted in the lowest LC50 value of 14.83 mg/L.

Terrestrial plants:

From tested plant species (cotton, rice, ryegrass), cotton was the most susceptible with dying plants at a concentration of 0.268 mg/g soil (second highest of four tested concentrations: 0.0671, 0.134, 0.286 and 0.537 mg/g soil, provided in 0.25 ml water per g soil).

At the highest concentration, cotton and rice died, ryegrass showed damage.

Conclusion on classification

The most sensitive species is Bracydanio rerio (fish): LC50 (96h) = 14.83 mg/kg.

The submission substance proved to be inherently biodegradable (>95% within 10 days) in a reliable Zahn-Wellens-test. In addition, in a (scarcely documented, therefore RL3) Closed Bottle test the substance was ready biodegradable. Also, QSAR models (EpiWin) predict good biodegradation.

Furthermore, the substance is degraded abiotically upon UV-irradiation. In analogy to other aromatic aldehydes such as benzaldehyde fast oxidation to the corresponding carboxylic acid (and further degradation) can be assumed. Taken together this leads to the conclusion that the substance is considerered to be degraded rapidly. No classification regarding environmental effects is proposed.