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EC number: 201-956-3 | CAS number: 89-98-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
In a study according to existing guidelines an oral LD50 of 3150 mg/kg has been established in female rats. No deaths were recorded in a guideline study on acute inhalative toxicity in rats which were exposed to vapour concentrations up to 1203 mg/m3 (technically maximal achievable concentration). No valid data on acute toxicity after dermal, intraperitoneal or intravenous application are available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06 December 1984 to 21 December 1984
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well performed study according to existing guidelines
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes
- Remarks:
- according to OECD principles
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG, Kastengrund, SPF
- Age at study initiation: no data
- Weight at study initiation: males: 162 g - 190 g (average 177 g); females: 161 g - 193 g (average 173 g)
- Fasting period before study: about 16 hours
- Housing: 5 animals per makrolon cage
- Diet: Altromin 1324 rat diet, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3°C
- Humidity (%): 50 +/- 20%
- Air changes (per hr): no data
- Photoperiod: 12 hrs dark / 12 hrs light
- Route of administration:
- oral: gavage
- Vehicle:
- other: Sesame oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25%
MAXIMUM DOSE VOLUME APPLIED: 5, 8, 12.6, 20 ml/kg bw - Doses:
- 1250, 2000, 3150, 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: weekly
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology, histopathology - Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 150 mg/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 3 150 - <= 5 000 mg/kg bw
- Mortality:
- see below
- Clinical signs:
- other: Decreased spontaneous activity, stupor, flanks pinched in, ataxic gait, squatting posture, prone position, ruffled fur, palpebral fissure narrow, panting, decreased respiration rate, mucilaginous feces. Clinical signs were reversible four days after ap
- Gross pathology:
- gross pathology of the animals which died:
stomach plump filled with food, yellowish to yellowish-green jelly mass in the small intestine, dark coloured adrenals, bladder plump filled, lung plethora;
no macroscopic findings in the animals which survived till the end of the study - Interpretation of results:
- not classified
- Remarks:
- Migrated information concluded by submitter Criteria used for interpretation of results: EU
- Conclusions:
- LD50 values for acute oral toxicity in male and female Wistar rats are between 3150 and 5000 mg/kg bw.
- Executive summary:
Acute oral toxicity of 2-chlorobenzaldehyde has been investigated in male and female rats (5 animals per sex per dose). LD50 values for male rats were between 3150 and 5000 mg/kg bw and about 3150 mg/kg bw for female rats.
This well performed guideline study, which was in accordance with GLP principles has been judged to be reliable without restrictions (RL1) and was selected as key study. The test item has not to be classified according to the criteria of the EU directive 83/467/EWG.
Reference
mortality:
mortality | ||||
dose | males | females | ||
mg/kg bw | absolut | relative (%) | absolut | relative (%) |
1250 | 0/5 | 0 | 0/5 | 0 |
2000 | 0/5 | 0 | 0/5 | 0 |
3150 | 1/5 | 20 | 2/5 | 40 |
5000 | 5/5 | 100 | 5/5 | 100 |
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 3 150 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating conc.
- Value:
- 1 203 mg/m³ air
- Quality of whole database:
- Based on the results of this study the LC50 of 2-chlorobenzaldehyde is greater than the maximal technical achievable concentration of 1203 mg/m3.
Additional information
In a guideline conform study the LD50 after oral application was 3150 mg/kg for female rats and 3150 -5000 mg/kg for male rats. This study was selected as key study for the evaluation of acute toxicity after oral application (RL1). The findings of the key study are supported by three other studies of minor reliability (RL3 or RL4), which reported a little bit lower LD50 values (LD50 rat: 2160 or 2475 mg/kg).
Acute toxicity after inhalative exposure has been investigated in rats in a guideline conform study according to GLP principles (RL1). No deaths were recorded in rats exposed up to the technically maximal achievable concentration of 1203 mg/m3 for 4 hours.
Reliable data on acute toxicity after dermal, intravenous or intraperitoneal application are currently not available.
Justification for classification or non-classification
2-Chlorobenzaldehyde has not to be classified for acute toxicity according to EU principles.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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