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EC number: 201-956-3
CAS number: 89-98-5
In a study according to existing guidelines an oral LD50 of 3150 mg/kg has been established in female rats. No deaths were recorded in a guideline study on acute inhalative toxicity in rats which were exposed to vapour concentrations up to 1203 mg/m3 (technically maximal achievable concentration). No valid data on acute toxicity after dermal, intraperitoneal or intravenous application are available.
Acute oral toxicity of 2-chlorobenzaldehyde has been investigated in
male and female rats (5 animals per sex per dose). LD50 values for male
rats were between 3150 and 5000 mg/kg bw and about 3150 mg/kg bw for
This well performed guideline study, which was in accordance with GLP
principles has been judged to be reliable without restrictions (RL1) and
was selected as key study. The test item has not to be classified
according to the criteria of the EU directive 83/467/EWG.
In a guideline conform study the LD50 after oral application was 3150
mg/kg for female rats and 3150 -5000 mg/kg for male rats. This study was
selected as key study for the evaluation of acute toxicity after oral
application (RL1). The findings of the key study are supported by three
other studies of minor reliability (RL3 or RL4), which reported a little
bit lower LD50 values (LD50 rat: 2160 or 2475 mg/kg).
Acute toxicity after inhalative exposure has been investigated in rats
in a guideline conform study according to GLP principles (RL1). No
deaths were recorded in rats exposed up to the technically maximal
achievable concentration of 1203 mg/m3 for 4 hours.
Reliable data on acute toxicity after dermal, intravenous or
intraperitoneal application are currently not available.
2-Chlorobenzaldehyde has not to be classified for acute toxicity
according to EU principles.
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