Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 201-956-3 | CAS number: 89-98-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Primary producers (aquatic plants or algae):
72h-EC50 = 16.8 mg/L (green alga, grwoth reduction)
72h-EC10 = 2.84 mg/L (green alga, grwoth reduction)
Primary consumers (aquatic invertebrates):
24h-EC50 = 30 mg/L (daphnia, immobility)
Secondary consumers (fresh water fish):
96h-LC50 = 14.83 mg/L (Brachydanio rerio, mortality)
Toxicity to microorganisms:
3h-EC50 = 132 mg/L (activated sludge, respiration inhibition)
Additional information
Primary producers (aquatic plants or algae):
In a 72 h growth inhibition test on freshwater green alga Desmodesmus subspicatus according to relevant guideline and performed complient to GLP (key study, reliability category 1) 2 -chlorobenzaldehyd was found to inhibit the growth after 72 h with the following effect values (geometric mean measured exposure concentrations, growth reduction, mg/L): NOEC = 2.25; LOEC = 7.41; EC10 = 2.84; EC20 = 3.46; EC50 = 16.8.
Primary consumers (aquatic invertebrates):
The reliable (with restrictions, RL 2) experimental key study was performed close to guideline OECD 202. The test duration however is only 24h (according to OECD 202 part I (1984) instead of 48 h. The validity criteria are fulfilled and a reference substance (potassium dichromate) confirms the reliability of the study. The values for acute toxicity of 2 -chlorobenzaldehyde on Daphnia magna are
EC0 = 21 mg/L
EC10 = 24 mg/L
EC50 = 30 mg/L.
Secondary consumers (fresh water fish):
The key study from Hoechst on Brachydanio rerio was performed according to OECD guideline 203 with a static system. Determination of actual test concentrations had been precluded because of substance instability (reliability category 2). The 96h LC50 value for Brachydanio rerio determined in this study is 14.83 mg/L.
Toxicity to microorganisms:
In a respiration inhibition test with activated sludge from a municipal sewage treatment plant performed according to OECD 209 and GLP (reliability category 1) the test item had been found to inhibit microbial respration by half at a concentration of 132 mg/L (EC50, 95% CI 60.3 - 331 mg/L ).
Thus, for the freshwater compartment of the three trophic levels tested, testing for acute fish toxicity resulted in the lowest LC50 value of 14.83 mg/L.
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