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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1979
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Insufficiently documented data from literature

Data source

Reference
Reference Type:
publication
Title:
Metabolism of toxic doses of o-chlorobenzylidene malonitrile (CS) in the rabbits
Author:
Paradowski M
Year:
1979
Bibliographic source:
Pol. J. Pharmacol. Pharm. 31, 563-572

Materials and methods

Principles of method if other than guideline:
acute intravenious toxicity
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): o-chlorobenzaldehyde
- Analytical purity: min. 98%, distilled freshly prior to use

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intravenous
Vehicle:
DMSO
Doses:
4 dose levels (not further specified)
No. of animals per sex per dose:
4 animals in each group (no information on sex of the animals)
Control animals:
not specified

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
8.5 other: mg/kg
95% CL:
6.5 - 11.2

Applicant's summary and conclusion

Executive summary:

The LD50 value of 2-chlorobenzaldehyde in rabbits after intravenious administration and 24 hrs observation period was 8.5 mg/kg bw.

The study has been judged not to be reliable (RL3) due to insufficient documentation.