Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-956-3 | CAS number: 89-98-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1979
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Insufficiently documented data from literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Metabolism of toxic doses of o-chlorobenzylidene malonitrile (CS) in the rabbits
- Author:
- Paradowski M
- Year:
- 1 979
- Bibliographic source:
- Pol. J. Pharmacol. Pharm. 31, 563-572
Materials and methods
- Principles of method if other than guideline:
- acute intravenious toxicity
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2-chlorobenzaldehyde
- EC Number:
- 201-956-3
- EC Name:
- 2-chlorobenzaldehyde
- Cas Number:
- 89-98-5
- Molecular formula:
- C7H5ClO
- IUPAC Name:
- 2-chlorobenzaldehyde
- Details on test material:
- - Name of test material (as cited in study report): o-chlorobenzaldehyde
- Analytical purity: min. 98%, distilled freshly prior to use
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- DMSO
- Doses:
- 4 dose levels (not further specified)
- No. of animals per sex per dose:
- 4 animals in each group (no information on sex of the animals)
- Control animals:
- not specified
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 8.5 other: mg/kg
- 95% CL:
- 6.5 - 11.2
Applicant's summary and conclusion
- Executive summary:
The LD50 value of 2-chlorobenzaldehyde in rabbits after intravenious administration and 24 hrs observation period was 8.5 mg/kg bw.
The study has been judged not to be reliable (RL3) due to insufficient documentation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
