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Long-term toxicity to fish

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Description of key information

NOEC (28 d) for Oncorhynchus mykiss = 0.14 mg/L (measured) related to mortality and sublethal effects (similar to OECD 215).
Nevertheless that endpoint is not used for PNEC-calculation as PNEC-values were calculated on the basis of a QSAR-model for chronic toxicity.

Key value for chemical safety assessment

Additional information

No chronic fish studies on toxic effects of AES (C12-18, 1-2.5EO) Na (CAS 68081-91-4) are available. Therefore, a read-across approach from the comparable alcohol ethoxysufate (C12-14, 2EO) Na (CAS 68891-38-3) is used to assess the long-term toxicity to fish. The results of that key study are supported by investigations with the pure AES homologue (C14, 2EO) Na (CAS 27731-62-0) and with the similar alcohol ethoxysulfate mixture (C14-16, 2EO) Na (CAS 68585-34-2).

To determine the toxic effect of the AES (C12-14, 2EO) Na a study similar to OECD guideline 215 was performed (TEGEWA, 1995). In this test juvenile individuals of rainbow trout (Oncorhynchus mykiss) were exposed to different concentrations of AES (C12 -14, 2EO) Na under flow-through conditions. Mortality and growth were determined over 28 days. Related to mortality and sublethal effects a NOEC of 0.14 mg/L (measured) was determined.

This result is supported by a non-GLP study carried out similar to OECD guideline 210, eggs of fathead minnow (Pimephales promelas) were exposed to the pure AES homologue (C14, 2EO) Na (Rawlings, P&G, 2004). Under flow-through conditions a NOEC (28 d) of 0.18 mg/L (measured) was determined. The NOEC based on mortality.

Two further studies are available for AES (C14-16, 2EO). In the first study fathead minnow fry were exposed in a flow-through system (Lewis and Hamm, P&G, 1979a). In the second study fathead minnow juveniles were exposed in the same way with the same mixture (Lewis and Hamm, P&G, 1979b). Both tests were conducted according to OECD 203 over 45 days. In both studies a NOEC for growth (length and weight) was reported to be 1.0 mg/L.