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EC number: 224-778-8 | CAS number: 4488-57-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
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- Flash point
- Auto flammability
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- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
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- Nanomaterial surface chemistry
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- Endpoint summary
- Stability
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- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, near guideline study, available as unpublished report, minor restrictions in design or reporting but otherwise adequate for assessment.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Abraded skin
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indene
- EC Number:
- 224-778-8
- EC Name:
- 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indene
- Cas Number:
- 4488-57-7
- Molecular formula:
- C10H14
- IUPAC Name:
- tricyclo[5.2.1.0²,⁶]dec-3-ene
- Reference substance name:
- Dihydrodicyclopentadiene
- IUPAC Name:
- Dihydrodicyclopentadiene
- Details on test material:
- - Name of test material (as cited in study report): DHDCPD
- Physical state: Liquid
- Density: 1.04 g/ml
- Analytical purity: Not reported
- Stability under test conditions: Not reported
- Storage condition of test material: Not reported
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: A USDA approved supplier (further details not reported)
- Weight at study initiation: 2.65-3.2 kg (males), 2.42-3.3 kg (females).
- Housing: Individually in stainless steel or galvanised cages.
- Diet : Charles River Rabbit chow (ad libitum)
- Water : Tap water (ad libitum)
- Acclimation period: 2 weeks
ENVIRONMENTAL CONDITIONS - not reported
IN-LIFE DATES: From: 16th January 1980 To: 30th January 1980
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area clipped 24 hours prior to dosing. Just prior to dosing the skin was abraded longitudinally every 2-3 cm over the dosing area, deep enough to penetrate the stratum corneum but not so deep as to disturb the derma or produce bleeding.
- Area of exposure: 4" x 12"
- % coverage: 10%
- Type of wrap if used: gauze
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Area thoroughly wiped
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): Administered as received (denity 1.04 g/ml).
- Constant volume or concentration used: yes - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: 3 times per day on day of dosing and twice daily thereafter for 14 days.
- Frequency of weighing: Pre-fast, post-fast, day 7 and day 14.
Animals which did not survive were weighed at the time of death or at the time when they were found dead.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: 1 male died on day 12.
- Mortality:
- 1 male rabbit (no. 5) died on day 12 of the 14-day observation period.
- Clinical signs:
- other: Decreased activity and ataxia were seen in all animals after dosing. Redness of the back was seen in 4 males and 5 females. Diarrhoea and/or soft stools was seen in some animals. 1 male had a bloody nose caused by thrashing in the cage after wrapping.
- Gross pathology:
- The following findings were were seen in several animals : pale and/or granular spleen; pale kidneys.
The following findings were were seen in individual animals: mottled or pale lungs; granular or mottled/pale liver.
Any other information on results incl. tables
Skin Irritation scores at 24.5 hours after application (Draize et al 1944).
Score |
Erythema |
Oedema |
3 (moderate to severe) |
3 males |
4 males and 1 female |
4 (Severe) |
2 males and 5 females |
1 male and 4 females |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 of dihydro dicyclopentadiene was greater than 2000 mg/kg to male and female rabbits, following application to abraded skin.
- Executive summary:
Groups of 5 male and 5 female New Zealand white rabbits rats were dosed with 2000 mg/kg of dihydrodicycolpentadiene as a 24- hour dermal application to abraded skin (under a semi-occlusive dressing) and were observed daily for 14 days after dosing. One male died on day 12 of the observation period. Decreased activity and ataxia was seen in all animals after dosing and redness of the back was seen in 4 males and 5 females. Diarrhoea and/or soft stools were seen in some animals. Weight loss or reduced weight gain was seen in 3/5 males and all females over the 14-day observation period. Gross necropsy findings, seen in several animals, included pale and/or granular spleen and/or pale kidneys. The LD50 was greater than 2000 mg/kg to rabbits following dermal application to abraded skin.
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