Registration Dossier
Registration Dossier
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EC number: 224-778-8 | CAS number: 4488-57-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
It is predicted that 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indene (TCDE) will be rapidly metabolised, similar to the proposed read-across substance, 3a,4,7,7a-tetrahydro-1H-4,7-methanoindene (DCPD).
Short description of key information on absorption rate:
In the absence of data, dermal absorption is assumed to be the default of 100%.
Key value for chemical safety assessment
- Absorption rate - dermal (%):
- 100
Additional information
There are no data available on the toxicokinetics of 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indene (TCDE) itself.
3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoindene (TCDE) and 3a,4,7,7a-tetrahydro-1H-4,7-methanoindene (DCPD) share much similarity in their chemical structures. TCDE has a single carbon-carbon double bond and may be considered similar to DCPD which has 2 non-conjugated carbon-carbon double bonds. In short TCDE may be viewed as being similar to DCPD, but with one less functional group.
Following exposure of three animal species to DCPD (Litton Bionetics, 1976; Ivie, 1980), the majority of the radioactivity was removed from plasma, within about 24 hours, to urine. Urinary radioactivity was present as 6 -7 components; conjugates and no unchanged dicyclopentadiene was excreted. This is consistent with simple oxidation of one or both of the double bonds of DCPD followed by hydrolysis of the epoxide(s) products to diols followed by conjugation of each product with glucuronic acid and finally the conjugates being excreted in urine.
With TCDE a relatively simpler situation may exist, with oxidation confined to the only double bond present. Therefore the metabolites formed and finally excreted in the urine of animals administered TCDE (which contains a single double bond) are likely to be a subset of those of DCPD (which contains an additional double bond).
As the TCDE molecule is similar to the DCPD molecule, albeit with TCDE having reduced functionality and perhaps toxicity relative to DCPD, and in the absence of direct toxicology information on TCDE, it seems that the DCPD molecule may and therefore serve as a robust surrogate
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