3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indene

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: results of a literature review, published in peer reviewed literature, acceptable with restrictions

Data source

Reference

Reference Type:

publication

Title:

Odor as an aid to chemical safety: odor thresholds compared with threshold limit values and volatiles for 214 industrial chemicals in air and water dilution

Author:

Amoore JE & Hautala E

Year:

1983

Bibliographic source:

J. Appl. Toxicol. 1983 Vol 3 272-290

Materials and methods

Type of study / information:

Literature review of odour thresholds

Endpoint addressed:

respiratory irritation

Principles of method if other than guideline:

The literature has been reviewed to provide quantitative data on the odour thresholds of 214 chemicals. Data on the volatility, solubility, ionisation and water-air distribution ratio at 25ºC are included. A safe dilution factor and an odour safety factor are calculated.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3a,4,7,7a-tetrahydro-4,7-methanoindene

EC Number:

201-052-9

EC Name:

3a,4,7,7a-tetrahydro-4,7-methanoindene

Cas Number:

77-73-6

Molecular formula:

C10H12

IUPAC Name:

3a,4,7,7a-tetrahydro-1H-4,7-methanoindene

Constituent 2

Reference substance name:

dicyclopentadiene

IUPAC Name:

dicyclopentadiene

Method

Ethical approval:

not specified

Details on study design:

no data

Results and discussion

Results:

Air odour threshold dicylclopentadiene: 0.0057±1.9 ppm. Safe dilution factor: 720. Odour safety factor (based on TLV of 5 ppm): 870. More than 90% of distracted persons perceive warning of TLV concentration in the air.

Any other information on results incl. tables

Air-dilution odour thresholds. Threshold limit value: 5 ppm v/v. Volatility at 25ºC: 3600 ppm v/v.

Applicant's summary and conclusion

Conclusions:

Threshold limit value: 5 ppm v/v; Volatility at 25ºC: 3600 ppm v/v; Air odour threshold: 0.0057±1.9 ppm; Safe dilution factor: 720; Odour safety factor: 870; Odour safety class: A (more than 90% of distracted persons perceive warning of TLV concentration in the air)