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Description of key information

Short description of key information on bioaccumulation potential result: 
APGs are predicted to be bioavailable via the oral route.
APGs undergo stepwise hydrolysis into glucose and fatty alcohol, which is further oxidized to the corresponding fatty acid are incorporated in the citrus cycle and partly in normal fat metabolism, respectively.
Excretion is assumed to occur mainly via renal elimination. Tissue accumulation can be excluded.

Key value for chemical safety assessment

Additional information

Absorption: Oral absorption is predicted to be high. Data from a dermal absorption study with capryl glucoside give a very low dermal absorption of 0.01%.

Distribution: The substance will be hydrolysed and the hydrolysis products are very polar and are predicted to have no accumulation potential. They are expected to enter the urine shortly after systemic absorption.

Metabolism: APGs undergo stepwise hydrolysis into glucose and fatty alcohol, which is further oxidized to the corresponding fatty acid are incorporated in the citrus cycle and partly in normal fat metabolism, respectively.

Excretion: Excretion is assumed to occur mainly via renal elimination. Tissue accumulation can be excluded.