Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-623-4 | CAS number: 13870-28-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study was performed similar to OECD TG 475, with the restriction that no positive controls were used. For justification for read across see endpoint summary.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Safety of anticorrosives in building water-pipe metal inhibitors sodium polyphosphate and sodium metasilicate.
- Author:
- Ito, R. et al.
- Year:
- 1 986
- Bibliographic source:
- Toxicol. Lett. 31 (Suppl. P1-28), 44
- Reference Type:
- publication
- Title:
- Safety of the metal scavengers sodium metasilicate and sodium polyphosphate.
- Author:
- Saiwai, K. et al.
- Year:
- 1 980
- Bibliographic source:
- Internal Report Toho University
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 004
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 475 (Mammalian Bone Marrow Chromosome Aberration Test)
- Deviations:
- not specified
- GLP compliance:
- no
- Type of assay:
- chromosome aberration assay
Test material
- Reference substance name:
- Disodium metasilicate
- EC Number:
- 229-912-9
- EC Name:
- Disodium metasilicate
- Cas Number:
- 6834-92-0
- IUPAC Name:
- disodium oxosilanediolate
- Details on test material:
- SOURCE: not reported
PURITY: not reported
IMPURITY/ADDITIVE/ETC.: not reported
ANY OTHER INFORMATION: the test substance was sodium metasilicate with an unknown concentration.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: BDF1
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- - Age: 9 weeks
Administration / exposure
- Route of administration:
- oral: feed
- Duration of treatment / exposure:
- 24 hours
- Frequency of treatment:
- once, 4 mg/kg bw colchicine was administered intraperitoneally 2 hours before necropsy.
- Post exposure period:
- sampling time was 24 h after administration
Doses / concentrations
- Remarks:
- Doses / Concentrations:
740-1340 mg/kg bw (7 graduated levels)
Basis:
nominal conc.
- No. of animals per sex per dose:
- 4 - 6
- Control animals:
- yes, concurrent vehicle
Examinations
- Tissues and cell types examined:
- femur bone marrow cells
- Evaluation criteria:
- The chromosomes were examined blind by three persons. Slides from femur bone marrow cells were prepared according to standard methods, and 100 metaphases per animal analyzed for chromosomal aberrations (including gaps, breaks, deletions, and exchanges).
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- No significant increase of chromosomal aberrations compared to negative control even at dosage levels exceeding the M.T.D. of 940 mg/kg bw.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
No significant increase of chromosomal aberrations compared to negative control even at dosage levels exceeding the M.T.D. of 940 mg/kg bw. - Executive summary:
Sodium metasilicate was tested in a cytogenetic test for chromosome aberrations in bone marrow cells of male mice in a study similar to OECD TG 475 with the restriction that no information on the use of positive controls was available. Groups of 4 - 6 animals were administered single oral doses of sodium metasilicate at dose levels between 740 and 1340 mg/kg bw (in total, seven dose levels were used in this study). Animals were sacrificed 24 hours after the last administration of the test substance; 2 hours before sacrifice a metaphase arresting agent (colchicine; 4 mg/kg bw) was injected intraperitoneally. Slides from femur bone marrow cells were prepared according to standard methods, and 100 metaphases per animal analyzed for chromosomal aberrations (including gaps, breaks, deletions, and exchanges). No indication of chromosomal aberrations was detected. In a range-finding study, no mortality occurred within 4 days after administration in animals dosed up to 940 mg/kg bw. Mortality occurred at higher doses (Saiwai et al. 1980).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.