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Registration Dossier
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EC number: 237-623-4 | CAS number: 13870-28-5
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-guideline study with sufficient detail. For justification of read across see endpoint summary.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Antitesticular effect of metallic and rare earth salts.
- Author:
- Kamboj, V. P. and Kar, A. B.
- Year:
- 1 964
- Bibliographic source:
- J. Reprod. Fertil. 7, 21-28
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 004
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Observation of male reproduction organs
- GLP compliance:
- no
- Type of method:
- in vivo
Test material
- Reference substance name:
- Silicic acid, sodium salt
- EC Number:
- 215-687-4
- EC Name:
- Silicic acid, sodium salt
- Cas Number:
- 1344-09-8
- IUPAC Name:
- sodium hydroxy(oxo)silanolate
- Details on test material:
- SOURCE: Not indicated
PURITY: Not indicated
IMPURITY/ADDITIVE/ETC.: Not indicated
ANY OTHER INFORMATION: Molar ratio not indicated
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: swiss albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ORGANISMS
- weight at study initiation: 100-120 g
Administration / exposure
- Route of administration:
- other: intratesticularly or subcutaneously
- Vehicle:
- water
- Details on exposure:
- - Total volume applied: 0.2 mL
- Duration of treatment / exposure:
- once
- Frequency of treatment:
- once
- Duration of test:
- 7 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.08 mmole/kg bw
Basis:
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- EXAMINATIONS:
- Morphology of testis
- Histology of testis
- Weight of testis
- Spermatozoa in the ductus deferens
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- > 0.08 other: mmole/kg bw
- Based on:
- test mat.
- Sex:
- male
Observed effects
- Morphology: no alteration of the rat testis.
- Histology: no alteration of the rat testis.
- Organ weight: slight reduction in testis weight.
- Spermatozoa: no effect on spermatozoa in the ductus deferens of the rats.
Applicant's summary and conclusion
- Conclusions:
- No morphological or histological effects of testes were seen in either application route nor was there any effect on residual spermatozoa in the ductus deferens.
- Executive summary:
In a study by Kamboj and Kar (1964), male rats were injected subcutaneously and intratesticularly with doses of 0.08 mmole/kg sodium silicate. When the testes were examined 7 d after injection, Testicular weight was slightly reduced as compared to controls injected with sterile water.
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