Registration Dossier
Registration Dossier
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EC number: 237-623-4 | CAS number: 13870-28-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
A LLNA was conducted with disodium disilicate (delta-crystalline).
Based on the results of a preliminary test the substance was assessed for sensitising properties at concentrations of 0 (vehicle only), 6.25%, 12.5% and 25% (v/v) in an LLNA according to OECD 429. The study was performed on female CBA/CaOlaHsd mice; 5 animals were used per group. Acetone/olive oil (4:1 (v/v)) was used as vehicle.General clinical signs and mortality as well as bodyweight development were monitored during the study.
At the daily clinical observation the animals did not show any visible clinical symptoms and no case of mortality were observed. Body weight development was unaffected.
None of the three tested concentrations of the test item reached the stimulation index of 3.The stimulation indices were: at a concentration of 6.25% = 0.7; at a concentration of 12.5% = 0.6 and at a concentration of 25% = 0.7.The EC3 value could not be calculated.
The test item is regarded to have no skin sensitising properties.
Migrated from Short description of key information:
A LLNA was conducted with disodium disilicate (delta-crystalline). The test substance does not meet the criteria for EU or GHS-EU classification as sensitising to the skin.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
- Migrated from Short description of key information:
Based on handling and use disodium disilicate (delta-crystalline) is not sensitising to the respiratory system.
Justification for classification or non-classification
Disodium disilicate (delta-crystalline) is not considered to be skin or respiratory sensitising and therefore, has not to be classified/ labelled according to 67/548/EEC and CLP (GHS).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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