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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
27 January 2014 to 06 February 2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
no
Type of method:
flask method
Specific details on test material used for the study:
FAT 66042/Z TE
Lot. 0003340600
Water solubility:
380 g/L
Temp.:
20 °C
Remarks on result:
other: pH value is not available

Preliminary visual estimation of the n-octanol solubility

Appearance of the test mixtures in the preliminary test

Amount of test item in
mg
Total volume in
ml
Appearance of mixture
100 1 dissolved
200 1 dissolved

The preliminary visual experiments showed that the water solubility of the test item is >200 g/l. Therefore the water solubility had to be determined by the “flask method”.

Flask-method

Water solubility of the test item – experiments A to D

Experiment A B C D (Blank)
Amount of test item (mg) 2.5 2.5 2.5 /
Stirring time at 30 °C (h) 24 48 72 72
Aliquot of the flasks μl/10 ml 5/0,01/100/3/10 5/0,01/100/3/10 5/0,01/100/3/10 5/0,01/100/3/10
Measured concentration (μg/ml) 9.5 11.1 11.4 /
Water solubility (g/l) 317 370 380 /

Concentrations of standards for recheck:

Standard Measured concentration
(μg/ml)
Recovery rate
Standard 1 (c = 0.92 μg/ml) 0.91 98.9 %
Standard 2 (c = 2.30 μg/ml) 2.32 100.9 %
Standard 4 (c = 9.20 μg/ml) 9.22 100.2 %

Recovery range from 98,9 % to 100,9 % indicates a sufficient accuracy of the analytical method.

Conclusions:
The water solubility of the test item at a temperature of 20 °C was 380 g/l.
Executive summary:

The water solubility was performed according to OECD guideline 105 using flask method. Based on the study results, the water solubility cs of the test item at a temperature of 20 °C was (without correction for the purity) 380 g/l.

Description of key information

The water solubility was performed according to OECD guideline 105 using flask method. Based on the study results, the water solubility cs of the test item at a temperature of 20 °C was (without correction for the purity) 380 g/l.

Key value for chemical safety assessment

Water solubility:
380 g/L
at the temperature of:
20 °C

Additional information