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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
19 July 2010 to 22 July 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods
Justification for type of information:
Read-across based on grouping of substances (category approach). A detailed category justification is included in chapter 13 of this dossier.
Qualifier:
according to guideline
Guideline:
other: Laser diffraction method according to ISO 13320-01
Deviations:
no
Principles of method if other than guideline:
Laser light scattering. The particle size distribution was analysed using the Mastersizer 2000 tool, which uses the technique of laser diffraction to measure the size of particles. It does this by measuring the intensity of light scattered as a laser beam passes through a dispersed particulate sample. This data is then analysed to calculate the size of the particles that created the scattering pattern.
GLP compliance:
no
Type of method:
Laser scattering/diffraction
Type of distribution:
volumetric distribution
Percentile:
D50
Mean:
128 µm
Remarks on result:
other: mean value of the 2 measurements (SD = 12.7)(migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.)
Percentile:
D10
Mean:
15 µm
St. dev.:
0.7
Remarks on result:
other: mean value of the two measurements
Percentile:
D90
Mean:
446 µm
St. dev.:
77
Remarks on result:
other: mean value of the two measurements

Measured mean particle size distribution:

Preparation d(0.1) [μm] d(0.5) [μm] d(0.9) [μm] d(3.2) [μm] d(4,3) [μm]
1 14 120 399 30 167
2 15 138 508 33 213
Mean* 14 128 446 31 190

Preparation <4 μm <10 μm <100 μm
Mean* (%) 3.13 7.06 43.73

*: using all single measuring points from the distributions 1 and 2, a new distribution is calculated, giving the mean values for each parameter.

Conclusions:
The mass median diameter of the test substance is 128 μm.
Executive summary:

The particle size distribution was analysed using the Mastersizer 2000 tool, which uses the technique of laser diffraction to measure the size of particles. It does this by measuring the intensity of light scattered as a laser beam passes through a dispersed particulate sample. This data is then analysed to calculate the size of the particles that created the scattering pattern.

Based on the study results, particle size: 3.13 % <3 µm, 7.06 % <10 µm and 43.73 % <100 µm.

The Mass Median Diameter is 128 µm. This value also is taken to define the Mass Median Aerodynamic Diameter (MMAD).

Description of key information

The particle size distribution was analysed using the Mastersizer 2000 tool, which uses the technique of laser diffraction to measure the size of particles. It does this by measuring the intensity of light scattered as a laser beam passes through a dispersed particulate sample. This data is then analysed to calculate the size of the particles that created the scattering pattern.

Based on the study results, particle size: 3.13 % < 3 µm, 7.06 % < 10 µm and 43.73 % < 100 µm.

The Mass Median Diameter is 128 µm.

Additional information