Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-406-7 | CAS number: 814-80-2
Endpoint summary
Administrative data
Description of key information
Repeated-dose toxicity should be considered a non-relevant end point for a biochemically essential substance, at least in the framework of normal toxicological testing.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
High levels of exposure to calcium lactate in the diet (up to 30% in feed) did not lead to any lactate-associated effects; all effects observed were due to the excessive intake of calcium. It could be concluded that any deleterious effects of lactic acid are caused by the effect of lactic acid on local pH, not on any biological effect of lactate.
High dermal exposure to lactate, in cosmetic creams, did not lead to any effects, with the exception of slight irritation at the highest doses.
Lactic acid is to be considered non-toxic; the only deleterious effects of lactic acid are due to local irritation as a result of decreased pH.
Justification for classification or non-classification
Lactic acid is to be considered non-toxic; the only deleterious effects of lactic acid are due to local irritation as a result of decreased pH.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
