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Registration Dossier
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EC number: 212-406-7 | CAS number: 814-80-2
Endpoint summary
Administrative data
Description of key information
Calcium lactate fully dissociates into Ca2+ ions and lactate. The toxicological effects of lactate can be understood in terms of the toxicological effect of lactic acid. Calcium ions - i.e. simple calcium salts, are non-toxic.
Despite being irritating to abraded rabbit skin, lactic acid is practically non-toxic by the oral, inhalation and dermal route.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 4 290 mg/kg bw
- Quality of whole database:
- Calcium lactate fully dissociates into Ca2+ ions and lactate. The toxicological effects of lactate can be understood in terms of the toxicological effect of lactic acid. Calcium ions - i.e. simple calcium salts, are non-toxic.
1 g lactic acid corresponds to 1.21 g calcium lactate
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 7 400 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 420 mg/kg bw
- Quality of whole database:
- Calcium lactate fully dissociates into Ca2+ ions and lactate. The toxicological effects of lactate can be understood in terms of the toxicological effect of lactic acid. Calcium ions - i.e. simple calcium salts, are non-toxic.
1 g lactic acid corresponds to 1.21 g calcium lactate
Additional information
Calcium lactate fully dissociates into Ca2+ ions and lactate. The toxicological effects of lactate can be understood in terms of the toxicological effect of lactic acid. Calcium ions - i.e. simple calcium salts, are non-toxic.
Lactic acid is a ubiquitous and essential biological molecule. It is, as is to be expected, practically non-toxic by all routes of exposure. Dermal exposure to 2000 mg/kg bw induced severe irritation, but no mortality. Oral administration of doses of 3500 mg/kg bw induce mortality, and lower doses induce clear signs of toxicity. All toxicity signs clearly point to (acid) irritation as the main or only mode of action. At 7400 mg/m3 lactic acid in air, one out of 5 female rats died in a 4 hour inhalation study. All symptoms observed in dead and surviving animals suggest (acid) irritation as the main or only mode of action.Justification for classification or non-classification
Calcium lactate fully dissociates into Ca2+ ions and lactate. The toxicological effects of lactate can be understood in terms of the toxicological effect of lactic acid. Calcium ions - i.e. simple calcium salts, are non-toxic.
Lactic acid is a ubiquitous and essential biological molecule. It is, as is to be expected, practically non-toxic by all routes of exposure.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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