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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Description of key information

The acute 24 and 48 h EC50 values of amides, C12-18 (even-numbered) and C18-unsatd., N-hydroxyethyl in freshwater invertebrates are 37.5 and 3 mg/L, respectively.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
3 mg/L

Additional information

An OECD guideline 202 study with deviations was conducted to evaluate the acute toxicity of amides, C12-18 (even-numbered) and C18-unsatd., N-hydroxyethyl to Daphnia magna under static conditions. Daphnia (20 per dose) were exposed at concentration ranges of 11- 250 mg/L for 24 hours and immobilitiy was determined. Based on the results, the 24 h EC0, EC50 and EC100 were 11.0, 37.5 and 64.0 mg/L, respectively (Gode, 2001b).

An OECD guideline 202 study was conducted to evaluate the acute toxicity of structurally similar amides, C18-18 (even numbered) and C18-unsatd., N-(hydroxyethyl) to Daphnia magna under static conditions.Daphnia (20 per dose) were exposed to the test substance in a concentration range of 0.10 - 10 mg/L for 48 hours and immobility was determined at 24 and 48 hours. Based on the results, the EC50 (24 h), EC50 (48 h) and NOEC (24 and 48 h) were determined to be 3.2, 3 and 1.8 mg/L, respectively (Wetton, 1996).