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EC number: 931-338-5
CAS number: 90622-77-8
dermal absorption study was conducted to evaluate the absorption of the
radiolabelled (14C) lauramide diethanolamine (LDEA) in the B6C3F1 mice.
50 µL of 50, 100 and 200 mg/kg bw and 30 µL of 800 mg/kg bw of LDEA was
applied to an area of 1x1 inch previously clipped skin, covered with a
non-occlusive patch. After 72 h of exposure, gauzes and aliquots of
urine, faeces, dermal rinse solutions and digested skin samples (in 2N
ethanolic sodium hydroxide) were collected and analysed for
radiochemical content. After 72 h of exposure, 50 to 70 % of the applied
doses were absorbed, and there were no statistically significant
differences in absorption across the range of doses. The disposition of
LDEA in the tissues was also similar across the four dose levels of 50,
100, 200 and 800 mg/kg bw.
study indicates 50 to 70% of the applied doses were absorbed, and there
were no statistically significant differences in absorption across the
range of doses. The disposition of LDEA in the tissues was also similar
for the four dose levels.
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