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EC number: 931-338-5
CAS number: 90622-77-8
Other examinations: Metabolism in rat and
human liver slices: LDEA
partitioned well into liver slices, and about 70% of the radioactive
LDEA was absorbed into the slices within 4h.The
absorbed radioactivity was present mostly as parent compound. About 20
and 43% of the radioactivity present in media from the un-induced and
DEHP-induced rats respectively were comprised of metabolites. About 30%
of the radioactivity in the media of the human liver slice incubations
was in the form of metabolites.
present in the incubation media from human and rat liver slices include
the half-acid amides identified as metabolites in vivo, parent LDEA, and
perhaps three other metabolites that have been identified as products of
ω - and ω-1 to 4 hydroxylation (Merdink et al., 1996).
A study was conducted to evaluate the
absorption, distribution, metabolism and excretion of radiolabelled
N,N-bis(2-hydroxyethyl)dodecanamide (LDEA) in F344 rats. Three male rats
were administered a single dose of (14C) LDEA at 1000 mg/kg bw by oral
gavage. Urine was collected 6 to 24 h post-dosing to isolate
metabolites. Tissue to blood ratios (TBR) was also determined by
collecting adipose tissue, blood, kidney and liver 72 h post-dosing. The
results of the investigation showed that LDEA was well absorbed and
mostly excreted in urine as two polar metabolites. Approximately 60 and
80 % of the dose was recovered in urine after 24 and 72 h, respectively,
and 9% of the dose was recovered in faeces after 72 h. The metabolites
were isolated and characterized as the half-acid amides of succinic and
of adipic acid. The TBRs were highest in the adipose and liver tissues,
with values of approximately 50. Under the study conditions, the
substance was well absorbed and mostly excreted in urine as two polar
metabolites (Mathews, 1996).
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