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EC number: 931-338-5
CAS number: 90622-77-8
Table 1: Scores
for corneal effects (opacity) according to Draize, 1959
6, 8, 10, 13, 17 and 21 d
Table 2: Scores
for iris effects according to Draize, 1959
8, 10, 13, 17 and 21 d
redness of the iris; * partial redness of the iris; c: circumcorneal
for conjunctival effects (redness, swelling exudation) according to
for conjunctival effects (redness, swelling, exudation) according to
Draize, 1959 (cont'd)
10 + 13 d
study was conducted to assess the eye irritation potential of
structurally similar amides, C18-18 (even numbered) and C18-unsatd.,
N-(hydroxyethyl) to rabbit eyes according to OECD guideline 405. 0.1 g
of ground neat test substance was placed in the lid of the right eye of
each rabbit. 72 hours after application, the treated eyes were analysed
for cornea damage using a Na-fluorescein solution, then rinsed with warm
physiological solution. Effects were evaluated at 1, 24, 48 and 72
hours, as well as at 6, 8, 10, 13, 17 and 21 days after application
according to Draize method.
Damage still present after 21 days was considered to be irreversible.
The mean overall score was 26.8 (maximum possible: 110). Under the
conditions of the study, the test substance was considered to be highly
irritating to rabbit eye based the irreversible effects noted in cornea
and iris of one animal
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