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EC number: 931-338-5
CAS number: 90622-77-8
study was conducted to evaluate the subchronic toxic effects of amides,
C8 -18 (even numbered) and C18-unsatd., N, N-bis(hydroxyethyl) when
administered by dermal route in B6C3F1 mice. The study was performed in
compliance with FDA GLP.
of 10 male and 10 female mice were administered 0, 25, 50, 100, 200,
400, or 800 mg/kg bw by dermal application for 14 wk.
mice survived until the end of the study. There were no treatment
related effects on body weight. The only treatment related clinical
finding was irritation of the skin at the site of application in males
and females administered 800 mg/kg bw. Weights of the liver and kidney
of 800 mg/kg bw males and females, liver of 400 mg/kg bw females, and
lung of 800 mg/kg bw females were significantly increased compared to
the vehicle controls. Epididymal spermatozoal concentration was
significantly increased in 800 mg/kg bw males. Histopathologic lesions
of the skin at the site of application included epidermal hyperplasia,
sebaceous gland hyperplasia, chronic active inflammation, parakeratosis,
and ulcer. The incidences and severities of these skin lesions generally
increased with increasing dose in males and females.
the test conditions, the NOAEL of amides, C8
-18 (even numbered) and C18-unsatd.,
N,N-bis(hydroxyethyl) was considered to be 50 mg/kg bw in mice.
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