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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Read-across from an analogue substance for which a guideline study (KIimish = 1) is available.
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH
See attached reporting format and read-across rationale.
Reason / purpose:
read-across source
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 117 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Remarks on result:
other: Based on a read-across from an analogue for which 48h-EC50 > 100 mg/L
Key result
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
>= 117 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Remarks on result:
other: Based on a read-across from an analogue for which 48h-NOEC >= 100 mg/L

The data matrix is included in the reporting format attached.

The results from the read-across approach are expressed on the basis of the amount of MPKO generated from the hydrolysis reaction of OS2600 and their molecular weights. The amount of MPKO was estimated using the assumption that 1 mole of the target substance OS2600 produces 3 moles of MPKO. No other adaptions are necessary.

Conclusions:
Based on the read-across approach from the analogue substance MPKO, the 48h-EC50 of OS2600 in Daphnia magna was determined to be >117 mg/L and the NOEC was >= 117 mg/L based on mobility.
Executive summary:

A short-term toxicity tests on aquatic invertebrates was performed on the analogue substance MPKO according to OECD Guideline 202. The 48h-NOEC based on immobility was determined to be ≥100 mg/L. Based on these results, the read-across approach was applied and the 48h-EC50 of OS2600 for Daphnia magna was determined to be >117 mg/L and the NOEC was >= 117 mg/L.

Description of key information

Based on the read-across approach from the analogue substance MPKO, the 48h-EC50 of OS2600 in Daphnia magna was determined to be >117 mg/L and the NOEC was >= 117 mg/L based on mobility.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
117 mg/L

Additional information

Key study: Read-across approach from experimental data on the analogue substance MPKO: A short-term toxicity tests on aquatic invertebrates was performed according to OECD Guideline 202 in Daphnia magna (GLP study). Based on the read-across approach from the experimental data on the analogue MPKO, the hydrolysis product of OS2600 (48h-EC50 > 100 mg/L and the 48h-NOEC >= 100 mg/L), the 48h-EC50 for OS2600 was determined to be >117 mg/L and the 48h-NOEC >= 117 mg/L.