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Melting point / freezing point

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Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15 March 2012-19 June 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
(2008)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
(1995)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Version / remarks:
(1998)
Deviations:
no
GLP compliance:
yes
Type of method:
differential scanning calorimetry
Key result
Melting / freezing pt.:
< -80 °C
Decomposition:
yes
Decomp. temp.:
> 150 °C
Remarks on result:
other: Melt/Freez pt: < 193 K; Decomp. temp: > 423 K

Preliminary TGA

From 175°C upwards the weight of the sample decreased significantly. At 327°C, the sample weight had decreased by 25%. After the experiment, brown/black residue was observed on the lid of the sample container and a brown/black residue remained in the sample container.

 

DSC experiment

During the cooling, no effects were observed that could indicate crystallization of the test substance. During heating, an exothermic effect was observed starting at 150°C. The effect was due to reaction and/or decomposition of the test substance. After the experiment, a brown/orange residue remained in the sample container.

 

Additional experiment

After storage overnight in the freezers at -20°C and -80°C the substance was a (highly viscous) liquid. From this it was concluded that the melting temperature of the test substance is < -80°C(< 193K).

 

Conclusions:
The melting temperature of the substance was determined to be < -80°C. Decomposition of the substance started at 150°C.
Executive summary:

In a differential scanning calorimetry study, the melting temperature of the substance was determined to be < -80°C. Decomposition of the substance started at 150°C. The study was performed in accordance with EC A.1, OECD 102 and EPA OPPTS 830.7200 guidelines and according to the principles of GLP.

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
Conducted with the hydrolysis product MPKO.
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
not specified
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
not specified
GLP compliance:
yes (incl. certificate)
Type of method:
thermal analysis
Key result
Melting / freezing pt.:
ca. -45 °C
Atm. press.:
ca. 101.7 kPa
Conclusions:
The melting point of MPKO is -45°C at an atmospheric pressure of ca. 101.7 kPa.
Executive summary:

The melting temperature of MPKO was determined using a Q100 difference scanning calorimeter. The melting point of MPKO is -45°C at an atmospheric pressure of ca. 101.7 kPa.

Description of key information

The melting temperature of the substance was determined to be < -80°C. Decomposition of the substance started at 150°C. The melting point of MPKO, the main hydrolysis product of OS2600 was determined to be -45°C

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
-80 °C

Additional information

Key study: The melting point test was performed on OS2600 in accordance with OECD Guideline 102 and EU method A.1. In a differential scanning calorimetry study, the melting temperature of the substance was determined to be < -80°C. Decomposition of the substance started at 150°C.

Supporting study: The melting temperature of the analogue substance MPKO was determined using a Q100 difference scanning calorimeter. The melting point was -45°C at an atmospheric pressure of ca. 101.7 kPa.