Registration Dossier
Registration Dossier
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EC number: 700-810-0 | CAS number: 58190-62-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
In accordance with Section 2 of REACH Annex XI, testing was omitted because it is technically not possible to conduct the study. OECD 121 and EC C.19 based on HPLC analysis are not applicable for determination of the adsorption coefficient due to the quick hydrolysis of the test substance (half-life time < 4 minutes). OECD 106 with a soil/water system is not applicable either because of the same reason. Calculation of the adsorption coefficient using a QSAR cannot be performed either since the partition coefficient cannot be determined. - Reason / purpose for cross-reference:
- data waiving: supporting information
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Conducted with the hydrolysis product MPKO.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Test temperature:
- 35 +- 1°C
- Details on study design: HPLC method:
- Instrument: Alliance Separation Module 2695 (Waters, Milford, MA, USA) Detector: Dual lambda Absorbance Detector 2487 (Waters) Column: 150 mm x 4.6 mm id. Hypersil BDS-CN; dp = 5 microm (Thermo, San Jose, CA?, USA) Column temperature: 35 +- 1 °C Mobile phase neutral pH: 30/70 (v/v) methanol/water Flow: 1 ml/min Injection volume: 10 microL UV detection: 210 nm
- Analytical monitoring:
- yes
- Key result
- Type:
- Koc
- Value:
- < 20.9
- Temp.:
- 35 °C
- Key result
- Type:
- log Koc
- Value:
- < 1.32
- Temp.:
- 35 °C
- Details on results (HPLC method):
- In the chromatogram of the test solution, one test substance peak was observed at a retention time of 2.6 minutes. Under the same analytical conditions, the retention time of phenol (log Koc = 1.32) was 3.1 minutes. Hence, it was concluded that the log Koc of the test substance was < 1.32 (Koc < 20.9).
- Validity criteria fulfilled:
- yes
- Conclusions:
- The Koc and log Koc value of MPKO at neutral pH were determined to be <20.9 and <1.32 respectively.
- Executive summary:
The adsorption coefficient (log Koc) of MPKO was determined by means of HPLC in accordance with OECD Guideline 121 and EU Method C19. In the chromatogram of the test solution, one test substance peak was observed at a retention time of 2.6 minutes. Under the same analytical conditions, the retention time of phenol (log Koc = 1.32) was 3.1 minutes. Hence, it was concluded that the log Koc of the test substance was < 1.32 (Koc < 20.9). The Koc and log Koc value of MPKO at neutral pH were determined to be < 20.9 and <1.32 respectively.
Referenceopen allclose all
pKa value for an acidic group in the molecular structure of the test substance was calculated using the Perrin calculation method:
RRC=NOH, pKa 12,49.
Description of key information
OS2600 shows quick hydrolysis in aqueous solutions. Therefore, the adsorption coefficient cannot be determined. However, the log Koc was determined for MPKO, the hydrolysis product of OS2600. It was determined to be < 1.32.
Key value for chemical safety assessment
- Koc at 20 °C:
- 20.9
Additional information
Data waiving (study not technically feasible): In accordance with Section 2 of REACH Annex XI, testing was omitted because it is technically not possible to conduct the study. OECD 121 and EC C.19 based on HPLC analysis are not applicable for determination of the adsorption coefficient due to the quick hydrolysis of the test substance (half-life time < 4 minutes). OECD 106 with a soil/water system is not applicable either because of the same reason. Calculation of the adsorption coefficient using a QSAR cannot be performed either since the partition coefficient cannot be determined.
Supporting study: The adsorption coefficient (log Koc) of MPKO was determined by means of HPLC in accordance with OECD Guideline 121 and EU Method C19 (GLP study). The Koc and log Koc value of the test substance at neutral pH were determined to be < 20.9 and <1.32 respectively.
[LogKoc: 1.32]
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