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Ecotoxicological information

Toxicity to microorganisms

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Reference
Endpoint:
toxicity to microorganisms
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Read-across from an analogue substance for which a guideline study (KIimish = 1) is available.
Justification for type of information:
See reporting format for the analogue approach attached.
Reason / purpose:
read-across source
Nominal and measured concentrations:

 
Key result
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
> 22.2 mg/L
Nominal / measured:
meas. (initial)
Conc. based on:
test mat.
Basis for effect:
other: CO2evolution
Remarks on result:
other: Based on a read-across from an analogue for which EC50 > 21.5 mg/L
Conclusions:
Based on the read-across approach from the analogue substance OS1600, the NOEC (28 days) of OS2600 for microorganism toxicity was determined to be 22.2 mg/L.
Executive summary:

Microbial toxicity was derived from an available ready biodegradation test performed with the analogue substance OS1600 in accordance with OECD Guideline 301B. Since in the toxicity control more than 25% degradation occurred within 14 days (32 % based on ThCO2) it was considered that the test substance does not inhibit microbial activity. The NOEC (28d) of OS1600 was determined to be 21.5 mg/L. Based on these results, the read-across approach was applied and the NOEC (28d) of OS2600 for microorganism toxicity was determined to be 22.2 mg/L.

Description of key information

Based on the read-across approach from the analogue substance OS1600, the NOEC (28 days) of OS2600 for microorganism toxicity was determined to be 22.2 mg/L since the test item does not inhibit microbial activity.

Key value for chemical safety assessment

EC10 or NOEC for microorganisms:
22.2 mg/L

Additional information

Key study: Read-across approach from experimental data on the analogue substance OS1600: Microbial toxicity was derived from an available ready biodegradation test performed with the analogue substance in accordance with OECD Guideline 301B (GLP study). Based on the read-across approach from the analogue substance OS1600 (NOEC = 21.5 mg/L), the NOEC for OS2600 was determined to be 22.2 mg/L for microorganism toxicity.