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EC number: 641-136-6 | CAS number: 1160164-88-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In Vitro:
A suite of in vitro mutagenicity studies were conducted on alcohols, C18-22, distillation residues (CAS No. 1160164-88-4), including the Ames test, in vitro mouse lymphoma assay and the CHO chromosome aberration assay. All these in vitro studies were negative for mutagenicity.
A GLP compliant OECD 471 bacterial reverse mutation assay was conducted with alcohols, C18-22, distillation residues (CAS No. 1160164-88-4). Revertant colonies were assessed following treatment with 6 / 20 / 60 / 200 / 600 / 2000 µg/plate of the test item in the absence and presence of S9 metabolic activation. It was concluded that the test item was not mutagenic in strains of Salmonella typhimurium and Escherichia coli, when tested in the absence and presence of metabolic activation up to and beyond its limit of solubility in the test system.
The mammalian cell gene mutation potential of alcohols, C18-22, distillation residues (CAS No. 1160164-88-4) was assessed in mouse lymphoma L5178Y cells. The test item was tested in the presence and absence of metabolic activation at doses of 25, 50, 100 and 200 µg/ml (not cytotoxic but up to precipitating concentrations). Alcohols, C18-22 distillation residues are not mutagenic in mouse lymphoma L5178Y cells, in either the absence or the presence of S9 mix, when tested in dimethylsulphoxide up to and beyond its limit of solubility in the test system.
A GLP compliant OECD 473 Chromosomal Aberrations Assay with Chinese Hamster Ovary Cell Cultures in vitro was conducted with alcohols, C18-22, distillation residues (CAS No. 1160164-88-4). It was concluded that alcohols, C18-22 distillation residues were not clastogenic when tested with Chinese hamster ovary cells in vitro, when tested up to a concentration of 200 µg/mL.
On the basis of the consistently negative study results from the in vitro genotoxicity data available (above), alcohols, C18-22 distillation residues are non-genotoxic.Short description of key information:
In Vitro
- Ames (OECD 471): Negative (+/- metabolic activation)
- In vitro mouse lymphoma assay (OECD 476): Negative (+/- metabolic activation)
- Chinese Hamster Ovary cell chromosome aberration assay (OECD 473): Negative (+/- metabolic activation)
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
These findings do not warrant the classification of alcohols, C18-22, distillation residues as genotoxic under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.