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Administrative data

Description of key information

An OECD 404 primary skin irritation study was conducted with alcohols, C18-22, distillation residues (CAS No. 1160164-88-4). No irritation was observed during the study and so the test item was concluded to be non-irritating to skin.
An OECD 405 eye irritation study was conducted with alcohols, C18-22, distillation residues (CAS No. 1160164-88-4). Signs of irritancy were clear by 72 hours. The test item was rated minimally irritating.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

SKIN: The skin irritancy potential of alcohols, C18-22, distillation residues (CAS No. 1160164-88-4) was examined in a reliable (Klimisch 1) GLP compliant OECD 404 skin irritation/corrosion study with three albino rabbits. The test substance was maintained in contact with the skin for 4 hours. No erythema or oedema was observed at anytime throughout the study. The primary irritation index was 0.0 and so the test item in this study was non-irritating to the skin.

 

EYE: In a reliable (Klimisch 1) GLP compliant OECD 405 study the eye irritancy potential of alcohols, C18-22, distillation residues (CAS No. 1160164-88-4) was assessed.The test substance, 0.1 mL by volume (33.1 mg) was placed into the conjunctival sac of the right eye of each animal selected for testing. All treated eyes were washed with room temperature deionized water for one minute immediately after recording the 24-hour observation. Signs of conjuctival irritation were clear by 72 hours, and the test substance was consequently rated minimally irritating to the eye. It should be noted that the extent of eye irritation was not sufficient to warrant classification under current EU regulations.

Justification for classification or non-classification

These findings do not warrant the classification of alcohols, C18-22, distillation residues as skin or ocular irritants under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.