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Study data for Behenyl Bottoms, characterized as Alcohols, C18-22, distillation residues (CAS No. 1160164-88-4),where available, has been evaluated and considered for assessment. Reliable data was available for short-term toxicity to invertebrates, short-term toxicity to fish, toxicity to algae, and toxicity to microorganisms. No reliable long-term data for fish or invertebrates were available. In a conservative approach the most sensitive study result related to each endpoint was chosen as Key and is summarized below.There was no reliable long-term toxicity data for fish, invertebrates, aquatic plants and waivers apply to these endpoints.  

 

Short-term Toxicity to Fish

One reliable (Klimisch 1) short-term toxicity study for fish was available for Behenyl Bottoms. The short-term toxicity of Behenyl Bottoms to the fathead minnow (Pimephales promelas) was reported by Palmer (2009) in an OECD 203 guideline and GLP compliant study. Fish were exposed to the test substance in measured concentrations for 96 hours, resulting in a 96-hr LC50 of >100 mg/L. 

 

Long-term Toxicity to Fish

Behenyl Bottoms are characterised as Alcohols,C18-22, distillation residues. According to REACH Annex IX, the studies required in Annex 9.1.6, are not needed for alcohols with carbon chains >C15 because sufficient information is available to predict no toxicity at their limit of solubility, based on experimental evidence presented in this dossier on the short-term aquatic toxicity to fish. Therefore, long-term toxicity to fish requirements are waived based on technical testing difficulties and an absence of short-term toxicity to aquatic organisms at the limit of solubility. No reliable measured long-term toxicity data to fish for constituents of Behenyl Bottoms is available. Predicted long-term toxicity (ChV) for fish by EPISuite (V4.11) using two representative components (docosan-1-ol and 2-decyltetradecanol)of Behenyl Bottoms indicates that no effects at saturation are expected for this endpoint.

Short-term Toxicity to Invertebrates

One reliable (Klimisch 1) short-term toxicity study for invertebrates was available for Behenyl Bottoms. The short-term toxicity of Behenyl Bottoms to Daphnia magna was reported by Palmer et al. (2009) in an OECD 202 guideline and GLP compliant study. Daphnia were exposed to the test substance in measured concentrations for 48 hours, resulting in a 48-hr EC50 of >100 mg/L. 

 

Long-term Toxicity to Invertebrates

Behenyl Bottoms are characterised as Alcohols, C18-22, distillation residues. According to REACH Annex IX, the studies required in Annex 9.1.5, are not needed for alcohols with carbon chains >C15 because sufficient information is available to predict no toxicity at their limit of solubility, based on experimental evidence presented in this dossier on the short-term aquatic toxicity to invertebrates. Therefore, long-term toxicity to invertebrate requirements are waived based on technical testing difficulties and an absence of short-term toxicity to aquatic organisms at the limit of solubility. No reliable measured long-term toxicity data to invertebrates for constituents of Behenyl Bottoms are available. Predicted long-term toxicity (ChV) for fish by EPISuite (V4.11) using two representative components(docosan-1-ol and2-decyltetradecanol)ofBehenyl Bottoms indicates thatno effects at saturation are expected for this endpoint.

 

Toxicity to Aquatic Algae

One reliable (Klimisch 1) toxicity study for aquatic algae was available for Behenyl Bottoms. The toxicity of Behenyl Bottoms to Pseudokirchnerella subcapitata was reported by Cartee et al., (2009) in an OECD 201 guideline and GLP compliant study. Algae was exposed to the test substance in measured concentrations for 72 hours, resulting in a 72-hr EC50 of >100 mg/L, based on growth, cell density and yield. The 72-hr NOEC, based on growth rate, was >100 mg/L.

 

Toxicity to Microorganisms

One reliable (Klimisch 1) toxicity study for microorganisms was available for Behenyl Bottoms. The toxicity of Behenyl Bottoms to activated sludge was reported by Schaefer & Twilly (2009) in an OECD 209 guideline and GLP compliant study. Activated sludge was exposed nominal concentrations of the test substance for 3 hours, resulting in a 3-hr LC50 of >1,000 mg/L, based respiration rate. 

In summary, study data for Behenyl Bottoms, characterized as Alcohols, C18 -22, distillation residues (CAS No. 1160164-88-4), where available, has been evaluated and considered for assessment. Reliable data was available for short-term toxicity to invertebrates, short-term toxicity to fish, toxicity to algae, and toxicity to microorganisms. No reliable long-term data for fish or invertebrates were available. Data requirements for long-term toxicity data for fish, invertebrates, and aquatic plants are waived.