Alcohols, C18-22, distn. residues

Endpoint summary

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not sensitising)

Additional information:

A reliable (Klimisch 1) GLP compliant OECD 406 guinea pig maximization test for topically applied test substances was conducted with alcohols, C18-22, distillation residues (CAS No. 1160164-88-4). Groups of 10 animals/sex received intradermal injections of the test item (corn oil vehicle) followed a week later by a topical application of the test item. A further two weeks later and the animals were challenged with a second topical application of the test item. The percentage of animals exhibiting erythema with or without edema after the challenge treatment was used to assign the test substance a sensitization potency rating. None of the test animals exhibited scores greater than 0, the test substance alcohols, C18 -22, distn. residues was given a sensitization potency rating of non-sensitizing (Grade 0).

Migrated from Short description of key information:
An OECD 406 guinea pig maximisation test was conducted in order to assess the sensitising potential of alcohols, C18-22, distillation residues (CAS No. 1160164-88-4). In this study no sensitizing reaction was observe in the test animals. Consequently on the basis of this study the test item was reported to be non-sensitising.

Justification for classification or non-classification

These findings do not warrant the classification of alcohols, C18-22, distillation residues as a sensitiser under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.