Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

A reliable (Klimisch 1) GLP compliant OECD 406 guinea pig maximization test for topically applied test substances was conducted with alcohols, C18-22, distillation residues (CAS No. 1160164-88-4). Groups of 10 animals/sex received intradermal injections of the test item (corn oil vehicle) followed a week later by a topical application of the test item. A further two weeks later and the animals were challenged with a second topical application of the test item. The percentage of animals exhibiting erythema with or without edema after the challenge treatment was used to assign the test substance a sensitization potency rating. None of the test animals exhibited scores greater than 0, the test substance alcohols, C18 -22, distn. residues was given a sensitization potency rating of non-sensitizing (Grade 0).

Migrated from Short description of key information:
An OECD 406 guinea pig maximisation test was conducted in order to assess the sensitising potential of alcohols, C18-22, distillation residues (CAS No. 1160164-88-4). In this study no sensitizing reaction was observe in the test animals. Consequently on the basis of this study the test item was reported to be non-sensitising.

Justification for classification or non-classification

These findings do not warrant the classification of alcohols, C18-22, distillation residues as a sensitiser under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.