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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

ORAL: An acute oral toxicity study in female Sprague-Dawley rats was conducted with Alcohols, C18-22, distn. residues. This study was conducted according to OECD 425 and was GLP compliant. On the basis of this study the acute oral LD50 for alcohols, C18-22, distillation residues was reported at >2000 mg/kg.bw in female rats.
DERMAL:  A reliable (Klimisch 1) acute dermal toxicity study was conducted in Sprague-Dawley rats (5/sex/dose) with Alcohols, C18-22, distn. residues. This study was conducted according to OECD 402 and was GLP compliant. On the basis of this study the acute dermal LD50 for Alcohols, C18-22, distn. Residues was reported at >2020 mg/kg.bw in male/female rats.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Value:
mg/kg bw

Additional information

ORAL: In a reliable (Klimisch 1) GLP compliant OECD 425 (up and down procedure) the acute oral toxicity of alcohols, C18-22, distillation residues (CAS No. 1160164-88-4) was assessed in female albino rats. No mortality occurred during the study. Clinical signs included salivation, crusting on muzzle, and polyuria in one animal, which were no longer evident by day 2. There was no effect on body weight gain in animals. The gross necropsy conducted at termination of the study revealed no observable abnormalities. The acute oral LD50 was estimated to be greater than 2000 mg/kg.

 

DERMAL: In a reliable GLP compliant OECD 402 study, the test substance, alcohols, C18-22, distillation residues (CAS No. 1160164-88-4), was evaluated for its dermal toxicity potential and relative skin irritancy when a single dose moistened with 1.0 mL of deionized water/g test substance, at a level of 2020 mg/kg, was applied to the intact skin of albino rats. No mortality occurred during the study. There was no effect on body weight gain with the exception of two animals that lost weight during the 1st week. The gross necropsy conducted at termination of the study revealed no observable abnormalities. The estimated LD50, as indicated by the data, was determined to be greater than 2020 mg/kg.

 

INHALATION: Physico-chemical properties of alcohols, C18-22, distillation residues can be used to assess whether there is a necessity for acute inhalation toxicity testing. In this instance alcohols, C18-22, distillation residues are of low volatility with a measured vapour pressure  < 3.69 x 10E-3 Pa at 20 °C and 25 °C. Consequently acute inhalation toxicity testing for this test item is not required.

Justification for classification or non-classification

The test substance, alcohols, C18-22, distillation residues is of low acute toxicity via ingestion (oral LD50 >2000mg/kg bw) or via dermal exposure (dermal LD50 >2020mg/kg bw). These findings do not warrant classification of alcohols, C18-22, distillation residues under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) do not warrant classification under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations (DSD/DPD).