Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary references: WoE

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1900

Materials and methods

Principles of method if other than guideline:
No data
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Effect levels
Remarks on result:
other: see Any Other Information

Any other information on results incl. tables

Acute oral

 

 

WoE

Since no original references are available only secondary references all available data is K4.

The available LD50s range from ± 1000 – 3000 mg/kg bw. Since most of the values are < 2000 mg/kg the substance is classified for acute oral toxicity: Acute oral Category 4.

 

Classification and Labeling

Acute oral Category 4.

LD50 rat: 1300 mg/kg (1000-1700 mg/kg)

 

 

The acute oral LD50 for 2-phenyl-2-propanol in rats was reported to be 1.3 g/kg (1.0–1.7 g/kg). Rats (10/dose) were dosed by orally at doses of 0.6, 0.85, 1.22, 1.73, 2.47, and 5.0 g/kg. Mortalities were 0, 3, 4, 6, 10, and 10 with increasing does; all animals died within 2 days of dosing. Clinical observations included lethargy, ataxia, loss of righting reflex, and coma. Necropsy observations included oral and nasal excretions, redness, yellowing and bloating in the intestines, red areas in stomach, dark lungs, and dark and/or mottled kidneys,

Moreno. O. M. (1977). Report to RIFM. 7 October. Cited in:Food and Chemical Toxicology. Vol. 20, Pg. 675, 1982

 

RIFM (Research Institute for Fragrance Materials, Inc.), 1977a. Acute Toxicity Study in Rats, Rabbits and Guinea Pigs. RIFM Report No. 1695, April 08. RIFM, Woodcliff Lake, NJ, USA. Cited in:Scognamiglio J,Jones L,Letizia CS,Api AM.Fragrance material review on 2-phenyl-2-propanol.Food Chem Toxicol.2012 Sep;50 Suppl 2:S130-3.

 

LD 50 rat: 1.07 ml/kg (± 1 g/m3, ± 1000 mg/kg)

Union carbide corp. unpublished data. Cited in:Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 4687

The oral LD50 in the rat ranged from 1400 to 3000 mg/kg. The oralLDin the rat of a mixture of 75% of the substance and 25% acetophenone was found to be 2000 mg/kg.

HERCULES INC; Technical Data Bulletin for Di-Cup (Dicumyl Peroxide) Including Toxicity Data for A-Methylstyrene, One of its Decomposition Products; 00/00/00; EPA No. 86-870001667; Fiche No. OTS0515743

LD50 rat: 2250 mg/kg

With clinical signs of toxicity similar to those of narcotics

Bukhalovskii, A. A. & Shugaev, B. B. (1976). Toksichnost i gigienicheskoe normirovanie izoforona, digidroizoforona

i dimetilfenilkarbinola.Promyshlennost Sillleticheskogo Kauchuka1976 (2), 4. Cited in:Food and Chemical Toxicology. Vol. 20, Pg. 675, 1982

LD50 mice: 1950 mg/kg

With clinical signs of toxicity similar to those of narcotics

Bukhalovskii, A. A. & Shugaev, B. B. (1976). Toksichnost i gigienicheskoe normirovanie izoforona, digidroizoforona

i dimetilfenilkarbinola.Promyshlennost Sillleticheskogo Kauchuka1976 (2), 4. Cited in:Food and Chemical Toxicology. Vol. 20, Pg. 675, 1982

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
Since no original references are available only secondary references all available data is K4. The available LD50s range from ± 1000 – 3000 mg/kg bw. Since most of the values are < 2000 mg/kg the substance is classified for acute oral toxicity: Acute oral Category 4.
Executive summary:

Since no original references are available only secondary references all available data is K4. The available LD50s range from ± 1000 – 3000 mg/kg bw. Since most of the values are < 2000 mg/kg the substance is classified for acute oral toxicity: Acute oral Category 4.