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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary reference

Data source

Materials and methods

Results and discussion

Effect levels
Remarks on result:
other: see Any Other Information

Any other information on results incl. tables

Acute dermal

Data lacking

No valid studies are available. The available study gets a K4 since no original references are available only secondary references.

The available LD50 is 4300 mg/kg bw.

 

Classification and Labeling

Since only one secondary reference is available the data is not sufficient for C&L purposes.

LD50 rabbit: 4300 mg/kg (2700-6900 mg/kg)

 

 

The acute dermal LD50 for 2-phenyl-2-propanol in rabbits was reported to be 4.3 g/kg (2.7–6.9 g/kg). Rabbits (4/dose) were treated with 1.25, 2.50, and 5.0 g/kg. No mortalities were reported at 1.25 or 2.5 g/kg. At 5 g/kg, two animals died on day 1 and one on day 2. Clinical signs included negative righting reflex, lethargy, and coma at 5 g/kg. Necropsy observations included oral and nasal excretions, red areas in the intestines, dark and/or mottled livers, dark areas in lungs, dark spleen, blood in bladder, and edematous, red, hard, and/or thick skin.

Moreno. O. M. (1977). Report to RIFM. 7 October. Cited in:Food and Chemical Toxicology. Vol. 20, Pg. 675, 1982

 

RIFM (Research Institute for Fragrance Materials, Inc.), 1977a. Acute Toxicity Study in Rats, Rabbits and Guinea Pigs. RIFM Report No. 1695, April 08. RIFM, Woodcliff Lake, NJ, USA. Cited in:Scognamiglio J,Jones L,Letizia CS,Api AM.Fragrance material review on 2-phenyl-2-propanol.Food Chem Toxicol.2012 Sep;50 Suppl 2:S130-3.

 

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
No valid studies are available. The available study gets a K4 since no original references are available only secondary references.
The available LD50 is 4300 mg/kg bw. Since only one secondary reference is available the data is not sufficient for C&L purposes.
Executive summary:

No valid studies are available. The available study gets a K4 since no original references are available only secondary references.

The available LD50 is 4300 mg/kg bw. Since only one secondary reference is available the data is not sufficient for C&L purposes.