Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1900

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

In vivo

Results
Remarks on result:
other: see Any Other Information

Any other information on results incl. tables

Eye corrosion/ irritation

WoE

No valid studies are available. All available data get a K4 since no original references are available only secondary references.

The results from animal studies show irritation to the eyes.The lack of individual scores and the use of a non-standard technique preclude classification on the basis of EU or GHS criteria. A precautionary approach is chosen and the substance is classified: Irritant, Category 2

 

Classification and Labeling

Irritant, Category 2

5 (Scale of 1 - 10; 1 = no observed reaction; 10 = most severe)

Union carbide corp. unpublished data. Cited in[Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 4687]

Application of 0.1 ml to the eyes of rabbits and 0.05 ml to the eyes of guinea pigs daily for 15 days produced some irritation with erythema. There was complete recoverywithin 7-14 days, with no permanent corneal damage.

HERCULES INC; Technical Data Bulletin for Di-Cup (Dicumyl Peroxide) Including Toxicity Data for A-Methylstyrene, One of its Decomposition Products; 00/00/00; EPA No. 86-870001667; Fiche No. OTS0515743

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Remarks:
Criteria used for interpretation of results: expert judgment
Conclusions:
No valid studies are available. All available data get a K4 since no original references are available only secondary references.
The results from animal studies show irritation to the eyes. The lack of individual scores and the use of a non-standard technique preclude classification on the basis of EU or GHS criteria. A precautionary approach is chosen and the substance is classified: Irritant, Category 2
Executive summary:

No valid studies are available. All available data get a K4 since no original references are available only secondary references.

The results from animal studies show irritation to the eyes. The lack of individual scores and the use of a non-standard technique preclude classification on the basis of EU or GHS criteria. A precautionary approach is chosen and the substance is classified: Irritant, Category 2