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Key value for chemical safety assessment

Effects on fertility

Additional information

The reproductive toxicity of high flash aromatic naphtha (C9 aromatics) was examined in a three generation study in which 30 rats of each sex (F0 generation) were exposed via inhalation to 100, 500, or 1500 ppm for 6 hrs/day, 5 days/week for 10 weeks prior to mating until GD20. This exposure regime was repeated for two subsequent generations. The results show no exposure related effects to fertility in either male or female rats. The NOAEL (inhalation) for reproductive toxicity for the P, F1, and F2 generation was >=1500 ppm.


Short description of key information:
Hydrocarbons, C9, aromatics, were examined for toxicity in a three-generation reproductive toxicity study. The NOAEL (inhalation) for reproductive toxicity for the P, F1, and F2 generation was >=1500 ppm.

Effects on developmental toxicity

Description of key information
Maternal (inhalation) NOAEL = 100 ppm
Developmental (inhalation) NOAEL = 100 ppm
Additional information

A study was conducted to determine the developmental toxicity of C9 aromatics in mice. Groups of 30 pregnant female mice were exposed via inhalation to 100, 500, or 1500 ppm for 6 hrs per day during gestation days 6 -15. The mice were sacrificed on gestation day 18, and examined for a variety of fetal developmental parameters including number of viable and nonviable fetuses, number of resorptions, total implantations, and number of corpea lutea. Animals were also examined for maternal toxicity signs including body weight, and changes in appearance and behaviour. There was a statistically significant reduction in body weight gain in dams and reduced mean body weight for fetuses in the 500 ppm exposure group, and therefore the LOAEC is 500 ppm for both maternal and developmental toxicity. There was no reduction in mean body weight or any other exposure related adverse effects for fetuses in the 100 ppm exposure group. Therefore, the maternal and developmental toxicity NOAEC = 100 ppm. The maternal toxicity LOAEC was 500 ppm based on significant reduction in weight gain for the dams. The development toxicity LOAEC was 500 ppm based on significant reduction in weight gain likely caused by the significant reduction in maternal body weight.

Justification for classification or non-classification