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EC number: 295-551-9 | CAS number: 92062-36-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
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- Flash point
- Auto flammability
- Flammability
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- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
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- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Skin Irritation – Hydrocarbons, C9, Aromatics are not corrosives and are mild to moderate dermal irritants for rabbit (OECD TG 404). A series of skin irritation studies were conducted using rabbits and standard test protocols. The mean erythema scores in the four independent key studies ranged from 1.9 to 4.0; mean edema scores in these same studies ranged from 0.0 to 2.2. Therefore, Hydrocarbons, C9 aromatics can be considered to be mildly to moderately irritating to the skin, with any effects generally reversible. In addition, a study was conducted in which 26 human volunteers were dermally exposed to C9 aromatics. Results showed no evidence of aromatics being a dermal irritant to humans. Using qualitative weight of evidence reasoning, the C9 Aromatics may cause mild skin irritation, but results are insufficient to classify.
Ocular Irritation – C9 Aromatics are not ocular irritating for rabbits (OECD TG 405). All study results indicate that the C9 Aromatics are not ocular irritants to rabbits.
Respiratory Irritation - No studies were located to indicate that C9 Aromatics are respiratory irritants. However, a constituent of the C9 Aromatics, 1,3,5-trimethylbenzene, is classified as an R37 respiratory irritant in Annex I.
Key value for chemical safety assessment
Additional information
Skin Irritation – Hydrocarbons,C9 Aromatics are not corrosives and are mild to moderate dermal irritants for rabbits (OECD TG 404). Topical application of Hydrocarbons, C9 Aromatics to the clipped backs of rabbits under semi-occlusive dressing for 4 hours elicited dermal responses in all animals. The mean erythema scores in the four independent key studies ranged from 1.9 to 4.0; mean edema scores in these same studies ranged from 0.0 to 2.2. Therefore, Hydrocarbons, C9 aromatics can be considered to be mildly to moderately irritating to rabbit skin, with any effects generally reversible. In addition, a study was conducted in which 26 human volunteers were dermally exposed to Hydrocarbons, C9 aromatics. Results showed no evidence of aromatics being a dermal irritant to humans. Using qualitative weight of evidence reasoning, the C9 Aromatics may cause mild skin irritation to rabbits, but are not irritating to human skin.
Ocular Irritation –Hydrocarbons, C9 Aromatics are not ocular irritants (OECD TG 405) when evaluated in rabbits following a single 0.1 ml ocular instillation. Testing of Hydrocarbons,C9 Aromatics generally demonstrated reversible conjunctive redness, chemosis, and infrequent discharge in animals. Draize scores were generally low. All study results indicate that the Hydrocarbons,C9 Aromatics are not irritating for rabbits.
Respiratory Irritation - No studies were located to indicate that Hydrocarbons, C9 Aromatics are respiratory irritants. However, a constituent of the Hydrocarbons, C9 Aromatics, 1,3,5-trimethylbenzene, is classified as an R37 respiratory irritant in Annex I.
Justification for classification or non-classification
SKIN IRRITATION: Erythema and edema scores (24, 48, and 72 average) in a human volunteer skin irritation study the scores are below the classification threshold requirements: 2.0, Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparation; 2.3, the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
OCULAR IRRITATION: Ocular lesion scores (24, 48, and 72 average) are below the classification threshold requirements.
Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparation: 0, cornea opacity; 0, iris lesion; >2.5, redness of the conjunctivae; >2.0, oedema of the conjunctivae (chemosis).
Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP): 0, cornea opacity; 0, iris lesion; >2.0, redness of the conjunctivae; >2.0, oedema of the conjunctivae (chemosis).
RESPIRATORY IRRITATION - There are no studies that warrant classification as a respiratory irritant under either the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC or under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP). However, a constituent of the C9 Aromatics, 1,3,5-trimethylbenzene, is classified as an R37 respiratory irritant in Annex I.
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