Registration Dossier
Registration Dossier
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EC number: 295-551-9 | CAS number: 92062-36-7
Endpoint summary
Administrative data
Description of key information
Acute Toxicity-Oral LD50=3592 mg/kg in rats (OECD TG 401)
Acute Toxicity-Dermal LD50>3160 mg/kg bw in rabbits (OECD TG 402)
Acute Toxicity-Inhalation LC50> maximal attainable vapor concentration in rats (OECD TG 403)
Key value for chemical safety assessment
Additional information
Acute toxicity studies on Hydrocarbons, C9, aromatics
were carried out for each of the three potential routes of exposure. Additional oral toxicity and inhalation toxicity studies are available. The studies discussed below represent the key studies. Male rats exposed orally toHydrocarbons, C9, aromatics
exhibited no mortality at the highest concentration tested and therefore the LD50 was >8 mL/kg. One female rat at the 4 mL/kg dose and two females at the 8 mL/kg dose died on day 7 of the study. The LD50 for female rats was 4 mL/kg (equivalent to 3592 mg/kg bw) therefore, the test substance is not classifiable. The acute study conducted via the inhalation route resulted in no acute toxicity at the maximally attainable vapor concentration, which was 6193 mg/m3. Similarly, no mortality was observed at the highest dermal dose examined, resulting in an LD50 >3160 mg/kg. The acute toxicity of Hydrocarbons, C9, aromatics would have to be considered of very low concern and are not classifiable under EU CLP.Justification for classification or non-classification
The test substance,Hydrocarbons, C9 Aromatics, is minimally toxic via ingestion where the LD50 is 3592 mg/kg, via dermal exposure where the LD50 is >3160 mg/kg, and by inhalation where the LC50 > maximal attainable vapor concentration in rats. These findings do not warrant classification of Hydrocarbons, C9, Aromatics under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) do not warrant classification under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations (DSD/DPD). The test substance, Hydrocarbons, C9, aromatics, is classified under EU CLP guidelines as a Category 1 aspiration hazard based on its physical and chemical properties (hydrocarbon fluid, viscosity ≤ 20,5 mm2/s) and as an R65 aspiration hazard under the EU DSD/DPD.
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