Tetrahydrofurfuryl alcohol

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2014-06-18 to 2014-06-19

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

isoteniscope

Key result

Test no.:

#1

Temp.:

25 °C

Vapour pressure:

142 Pa

Remarks on result:

other: The result was extrapolated from measurements made at elevated temperature and therefore the reviewer has attempted to assess the uncertainty associated with the extrapolation.

Key result

Test no.:

#2

Temp.:

20 °C

Vapour pressure:

ca. 100 Pa

Key result

Test no.:

#3

Temp.:

30 °C

Vapour pressure:

ca. 180 Pa

Key result

Test no.:

#4

Temp.:

40 °C

Vapour pressure:

ca. 340 Pa

Key result

Test no.:

#5

Temp.:

50 °C

Vapour pressure:

ca. 600 Pa

Transition / decomposition:

no

Recorded temperatures, manometer readings and resulting calculated values of vapour pressure are shown in the tables below

Run 1

Table 1: vapour pressure data

LHS column (cmHg)	RHS column (cmHg)	Temperature (°C)	Vapour pressure (Pa)	Temperature (K)	Reciprocal temperature (1/K)	log10VP
56.1	14.9	157.0	54928.82	430.15	0.002324770	4.739800236
55.6	15.4	156.0	53595.59	429.15	0.002330188	4.729129073
54.5	16.5	154.1	50662.50	427.25	0.002340550	4.704686617
53.9	17.1	152.8	49062.63	425.95	0.002347693	4.690750839
53.2	17.8	151.6	47196.12	424.75	0.002354326	4.673906282
52.5	18.5	150.4	45329.61	423.55	0.002360996	4.656381937
51.4	19.6	148.3	42396.51	421.45	0.002372761	4.627330140
50.7	20.3	147.0	40530.00	420.15	0.002380102	4.607776604
50.0	21.0	145.6	38663.49	418.75	0.002388060	4.587301018
49.3	21.7	144.2	36796.97	417.35	0.002396070	4.565812102
48.7	22.3	142.9	35197.11	416.05	0.002403557	4.546506947
47.6	23.4	140.4	32264.01	413.55	0.002418087	4.508718386
47.1	23.9	139.2	30930.79	412.35	0.002425124	4.490391005
46.9	24.1	138.1	30397.50	411.25	0.002431611	4.482837867
46.0	25.0	136.4	27997.70	409.55	0.002441704	4.447122315
45.7	25.3	135.4	27197.76	408.55	0.002447681	4.434533188
45.3	25.7	134.0	26131.18	407.15	0.002456097	4.417159091
44.8	26.2	132.8	24797.96	405.95	0.002463358	4.394415964
44.4	26.6	131.6	23731.38	404.75	0.002470661	4.375323022
43.9	27.1	130.0	22398.16	403.15	0.002480466	4.350212302
43.5	27.5	128.6	21331.58	401.75	0.002489110	4.329023003
43.2	27.8	127.5	20531.64	400.65	0.002495944	4.312423741

 

A plot of log₁₀[vapour pressure (Pa)] versus reciprocal temperature [1/T(K)] for Run 1 gives the following statistical data using an unweighted least square treatment

Slope = -2.53x10³

Standard error in slope = 11.7

Intercept = 10.6

Standard error in intercept = 2.81x10^-2

The results indicated the following vapour pressure relationship:

log₁₀[vapour pressure (Pa)] = -2.53x10³/temp (K) + 10.6

This yields a vapour pressure (Pa) at 298.15 K with a common logarithm of 2.14

 

 

Run 2

Table 2: vapour pressure data

LHS column (cmHg)	RHS column (cmHg)	Temperature (°C)	Vapour pressure (Pa)	Temperature (K)	Reciprocal temperature (1/K)	log10VP
54.9	16.1	154.7	51729.08	427.85	0.002337268	4.713734746
54.5	16.5	153.8	50662.50	426.95	0.002342195	4.704686617
54.0	17.0	152.9	49329.28	426.05	0.002347142	4.693104744
53.2	17.8	151.5	47196.12	424.65	0.002354880	4.673906282
52.6	18.4	150.4	45596.25	423.55	0.002360996	4.658929126
52.0	19.0	149.2	43996.38	422.35	0.002367705	4.643416960
51.4	19.6	148.2	42396.51	421.35	0.002373324	4.627330140
50.8	20.2	146.9	40796.64	420.05	0.002380669	4.610624447
50.1	20.9	145.5	38930.13	418.65	0.002388630	4.590285872
49.5	21.5	144.3	37330.26	417.45	0.002395496	4.572061051
48.9	22.1	142.8	35730.39	415.95	0.002404135	4.553037814
48.3	22.7	141.5	34130.53	414.65	0.002411672	4.533142985
47.5	23.5	139.6	31997.37	412.75	0.002422774	4.505114262
47.0	24.0	138.6	30664.14	411.75	0.002428658	4.486630856
46.8	24.2	137.7	30130.86	410.85	0.002433978	4.479011459
46.2	24.8	136.6	28530.99	409.75	0.002440513	4.455316793
45.3	25.7	134.1	26131.18	407.25	0.002455494	4.417159091
45.0	26.0	132.9	25331.25	406.05	0.002462751	4.403656621
44.5	26.5	131.6	23998.03	404.75	0.002470661	4.380175525
44.0	27.0	130.0	22664.80	403.15	0.002480466	4.355351942
43.6	27.4	128.8	21598.22	401.95	0.002487872	4.334418035
43.3	27.7	127.6	20798.29	400.75	0.002495321	4.318027618
43.0	28.0	126.3	19998.36	399.45	0.002503442	4.300994279

 

A plot of log₁₀[vapour pressure (Pa)] versus reciprocal temperature [1/T(K)] for Run 2 gives the following statistical data using an unweighted least square treatment

Slope = -2.53x10³

Standard error in slope = 9.85

Intercept = 10.6

Standard error in intercept = 2.38x10^-2

The results indicated the following vapour pressure relationship:

log₁₀[vapour pressure (Pa)] = -2.53x10³/temp (K) + 10.6

This yields a vapour pressure (Pa) at 298.15 K with a common logarithm of 2.15

 

Run 3

Table 3: vapour pressure data

LHS column (cmHg)	RHS column (cmHg)	Temperature (°C)	Vapour pressure (Pa)	Temperature (K)	Reciprocal temperature (1/K)	log10VP
56.9	14.1	159.2	57061.97	432.35	0.002312941	4.756346789
55.8	15.2	157.7	54128.88	430.85	0.002320993	4.733429054
55.1	15.9	156.5	52262.37	429.65	0.002327476	4.718189087
54.1	16.9	154.6	49595.92	427.75	0.002337814	4.695445960
53.3	17.7	153.5	47462.76	426.65	0.002343842	4.676353018
52.5	18.5	152.0	45329.61	425.15	0.002352111	4.656381937
51.0	20.0	149.0	41329.93	422.15	0.002368826	4.616264714
50.0	21.0	147.1	38663.49	420.25	0.002379536	4.587301018
49.0	22.0	144.6	35997.04	417.75	0.002393776	4.556266784
48.7	22.3	144.1	35197.11	417.25	0.002396645	4.546506947
47.7	23.3	142.0	32530.66	415.15	0.002408768	4.512292846
47.0	24.0	139.6	30664.14	412.75	0.002422774	4.486630856
46.0	25.0	137.4	27997.70	410.55	0.002435757	4.447122315
45.5	25.5	136.0	26664.47	409.15	0.002444091	4.425933016
44.9	26.1	134.0	25064.61	407.15	0.002456097	4.399060869
44.0	27.0	130.8	22664.80	403.95	0.002475554	4.355351942
43.2	27.8	128.0	20531.64	401.15	0.002492833	4.312423741
42.4	28.6	125.7	18398.49	398.85	0.002507208	4.264782107

 

A plot of log₁₀[vapour pressure (Pa)] versus reciprocal temperature [1/T(K)] for Run 3 gives the following statistical data using an unweighted least square treatment

Slope = -2.49x10³

Standard error in slope = 13.3

Intercept = 10.5

Standard error in intercept = 3.18x10^-2

The results indicated the following vapour pressure relationship:

log₁₀[vapour pressure (Pa)] = -2.49x10³/temp (K) + 10.5

This yields a vapour pressure (Pa) at 298.15 K with a common logarithm of 2.17

 

Summary of results

The extrapolated vapour pressure for each measurement is summarised in Table 4

Table 4: summary of vapour pressure data

run	log10[vapour pressure (Pa)] at 25°C
1	2.14
2	2.15
3	2.17
Mean	2.15
vapour pressure	142

 

The test item did not change in appearance under the conditions of the study

Reviewer's comment: The result (142 Pa) was extrapolated from measurements made at elevated temperature and therefore the reviewer has attempted to assess the uncertainty associated with the extrapolation. Based on the raw data, the reviewer has estimated the vapour pressure of the substance to be 142±13 Pa at 25°C.

Using the regression in the study report, the following vapour pressures at different temperatures were obtained by the reviewer.

	Run 1 (log VP)	Run 2 (log VP)	Run 3 (log VP)	Average	Vapour pressure (Pa)
20	1.969606	1.969606	2.006055	1.981756	95.8861
30	2.254297	2.254297	2.286244	2.264946	184.0542
40	2.520805	2.520805	2.548539	2.530049	338.8828
50	2.770819	2.770819	2.7946	2.778746	600.8218

Conclusions:

A vapour pressure of 142±13 Pa at 25°C was determined for the substance in accordance with OECD 104 and in compliance with GLP. The result is considered reliable.

Description of key information

Vapour pressure [tetrahydrofurfuryl alcohol]: 142±13 Pa at 25°C (OECD 104)

Key value for chemical safety assessment

Vapour pressure:

142 Pa

at the temperature of:

25 °C

Additional information

The vapour pressure of the submission substance has been recently determined. A vapour pressure of 142±13 Pa at 25°C was obtained for the substance using the isoteniscope method in accordance with OECD 104 and in compliance with GLP. The result was extrapolated from measurements at elevated temperature, the reviewer has therefore attempted to assess the uncertainty associated with the extrapolation. In addition, using the regression equations in the study report, vapour pressure values of approximately 100 Pa at 20°C, 180 Pa at 30°C, 340 Pa at 40°C and 600 Pa at 50°C were obtained by the study reviewer. The result is considered to be reliable and selected as key study. The key study is supported by a measured vapour pressure of 186 Pa at 25°C which was obtained for the substance in accordance with OECD 104 and in compliance with GLP. Also, a vapour pressure of 107 Pa at 25°C was reported from a reliable peer-reviewed source (Daubert and Danner 1989). The key study was selected as the most recent of the available reliable studies.

In secondary sources to which reliability could not be assigned, vapour pressures of 31 Pa at 20°C and 670 Pa at 50°C were reported for the substance. Similarly, in another secondary source (Pennakem 1973), raw vapour pressure results between temperature of 41 - 178°C were reported for the substance. Vapour pressure value of 2.3 mmHg (307 Pa) at 41.6°C was obtained for tetrahydrofurfuryl alcohol. Vapour pressure values of 82 Pa and 116 Pa at 20°C and 25°C were extrapolated by the reviewer from the raw data.

Variations in the vapour pressure of the substance may occur depending on the purity of the test substance and the test method used, however in the absence of a more reliable data, the vapour pressure result reported in the key study is used as a worst case value for assessment purposes.