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EC number: 940-783-4
CAS number: -
An acute dermal toxicity study was performed
with the test item in CRL:(WI) rats, in compliance with OECD Guideline
A limit test was carried out at 2000 mg/kg
body weight (bw) in both sexes (5 rats/sex). The test item was applied
as supplied as a single dermal 24-hour exposure followed by a 14-day
Clinical observations were performed on all
animals at 1 and 5 hours after dosing and on the surviving animals daily
for 14 days thereafter. Body weight was measured prior to dosing on Day
0 and on Days 7 and 14 and of the animal found dead. Gross macroscopic
examination was performed on the surviving animals at the end of the
2-week observation period (Day 14). Moreover, the animal found dead was
examined macroscopically and body weight was recorded at necropsy.
The results of the study were summarized as
Administration of the test item at a dose
level of 2000 mg/kg body weight caused mortality in 1/10 animal.
Systemic clinical signs
No clinical signs were observed after
treatment with the test item or during the 14-day observation period.
Local dermal signs
There were no observed local dermal signs
after treatment with the test item or during the 14 day observation
period at a dose level of 2000 mg/kg bw.
The body weight and body weight gain of
treated animals did not show any test item-related effect.
Dark/red discoloration/foci of the
non-collapsed lungs, foamy red material in the trachea and thymus and
red macule at the site of application were found in this female rat at
There was no evidence of the any gross
observations in surviving animals at a dose level of 2000 mg/kg bw and
terminated on Day 14.
The acute dermal median lethal dose (LD50)
of the test item was found to be higher than 2000 mg/kg bw in male and
female CRL:(WI) rats.
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