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EC number: 603-094-7
CAS number: 125904-11-2
A preliminary cytotoxicity test using 5
-bromo-2'deoxyuridine to detect any increase in the cell proliferation
kinetics in CHO cells was conducted at dosages ranging from 5 to 5000 µg/mL,
with and without S9 mix. The results indicated that concentration of 50
to 5000 µg/mL
without S9 mix were toxic to the cultures, resulting in no cell
survival. In cultures treated with S9 mix dosages of 250 to 5000 µg/mL
were toxic, resulting in no cell survival. On this basis 2.5, 10 and 35 µg/mL
without S9 mix and 9, 50 and 90 µg/mL
with S9 mix were evaluated in a first experiment. Negative results were
obtained without S9 mix. Parwise t-test, but not Chi-square analysis,
indicated a statistically significant increase in the proportion of
aberrations/cell at the highest dose level with S9 mix and therefore a
confirmatory assay was performed with S9 mix at dosages of 80, 90 and
Results of this second assay were negative.
test substance was judged as not-clastogenic with and without S9 mix
under the experimental conditions.
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