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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
28 August 2003 to 13 November 2003
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
yes
Type of method:
flask method
Water solubility:
6.91 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
5 other: mg/DBSL
Incubation duration:
>= 24 - <= 48 h
Temp.:
20 °C
Remarks on result:
other: pH not determined
Details on results:
Duplicate sub-samples were removed from the appropriate bottles after 24 and 48 hours of shaking in a water bath maintained at 30 ± 1.0°C and following 24 hours of equilibration at 20 ± 0.5°C. Analysis of these aqueous sub-samples yielded water solubility concentrations for DBS that were dependent on the component of the DBS test substance being monitored. Mean measured DBS concentrations for the 24 and 48-hour samples were well within the 15% criterion of the protocol. Consequently, analysis of the 72-hour sample was not required. The mean water solubility (n = 4) for DBS at 20 ºC were 6.91 ± 0.0871, 49.2 ± 1.45, and 1.03 ± 0.104 mg/L using the dibromo-, monobromo-, and tribromostyene as surrogates for the test substance, respectively, to quantitate DBS concentrations. For the dibromo-, monobromo-, and tribromostyrene components, the CV for the measured solubilities were 1.26%, 2.95%, and 10.1%, respectively.

No further information required.

Conclusions:
Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L) for all 3 components: dibromo-, monobromo-, and tribromostyrene
The solubility of DBS in HPLC-grade bottled reagent water was dependent on the component of the DBS test substance being monitored. The mean water solubility for DBS at 20 ºC was 6.91 ± 0.0871, 49.2 ± 1.45, and 1.03 ± 0.104 mg/L using the dibromo-, monobromo-, and tribromostyene surrogates for the test substance, respectively, to quantitate DBS concentrations.
Executive summary:

In line with OCED Guideline 105, the water solubility of DBS was determined using the shake-flask method. The solubility of DBS in HPLC-bottled reagent water was dependent on the component of DBS test substance being monitored. The mean water solubility (n=4) for DBS at 20 ºC was 6.91 ± 0.0871, 49.2 ± 1.45 and 1.03 ± 0.104 mg/L using the dibromostyrene, monobromostyrene and tribromostyrene surrogates for the test substance, respectively, to quantitate DBS concentrations.

Description of key information

The solubility of DBS in HPLC-grade bottled reagent water was dependent on the component of the DBS test substance being monitored. The mean water solubility for DBS at 20 ºC was 6.91 ± 0.0871, 49.2 ± 1.45, and 1.03 ± 0.104 mg/L using the dibromo-, monobromo-, and tribromostyene surrogates for the test substance, respectively, to quantitate DBS concentrations.

Key value for chemical safety assessment

Water solubility:
6.91 mg/L
at the temperature of:
20 °C

Additional information

The key study for this endpoint, Van Hoven, R.L. & Nixon, W.B. (2003) was performed in accordance with OECD guideline 105 and in compliance with GLP and was considered of a high reliability. Accordingly, the study was assigned a reliability score of 1 and was considered adequate for use as a standalone study to represent the water solubility of the substance.