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EC number: 603-094-7
CAS number: 125904-11-2
In an oral gavage 90-day study, groups of 20 male and female rats
received daily dosages of 130, 300, 700 or 1600 mg/kg bw/day. The
control group received the vehicle, corn oil, at a volume of 5 mL/kg bw.
Five animals/sex in each group remained on study following the dosing
period for a 30 -day recovery period. The animals were observed for
signs of toxicity and effects on body weight, food consumption, clinical
pathology parameters, ophthalmology and organ weights. Complete necropsy
examinations were performed on all animals. A complete list of organs
and tissues was examined microscopically in animals of the control and
high dose groups. The kidney, liver, peripheral nerve spinal cord,
urinary bladder and gross lesions were examined microscopically from the
low and mid dose animals.
Dibromostyrene induced decreased male body weight and body weight gain
at 1600 mg/kg bw/day and increased food consumption in both sexes at
1600 mg/kg bw/day and in males at 700 mg/kg bw/day. Transitory
haematologic changes, possibly indicative of compensatory increased red
blood cell production were apparent at the 30 -day evaluation in both
sexes at 1600 mg/kg bw/day and, to a much lesser extent in the 300 and
700 mg/kg bw/day groups; some evidence of these haematologic changes
persisted to the 90 -day evaluation at the highest dose level.
Treatment-related hypoglicemia was present in the 300, 700 and 1600
mg/kg bw/day groups. Serum bromide and tissue bromine levels were
increased in all groups, generally in a dose-related pattern, at the 90
-day sacrifice. Test material-related liver weight increases were
observed in the 700 and 1600 mg/kg bw/day females at the 90 -day
sacrifice. Microscopic liver changes indicative of increased
detoxification requirement were present in the 700 and 1600 mg/kg bw/day
groups animals. Kidney and possibly urinary bladder changes were also
observed in the 1600 mg/kg bw/day group.
Essentially all evidence of toxicity subsided by the end of the recovery
period. No biologically significant differences between the control and
treated groups in body weight, body weight gain, food consumption,
haematology or serum chemistry values or microscopic pathology findings
were apparent for recovery animals. Increased liver weights in females
previously treated at 1600 mg/kg bw/day persisted to the end of
recovery, however, the magnitude of the increase was less than at the 90
-day sacrifice and no microscopic finding accompanied this increase.
The dosage of 130 mg/kg bw/day was found to be the No Observable Effect
Level (NOEL) for systemic toxicity.
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